日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bumped Kinase Inhibitor BKI-1708 Interferes in Cytokinesis and Drives Baryzoite Conversion in the Cyst-Forming Apicomplexan Parasites Toxoplasma gondii, Neospora caninum and Besnoitia besnoiti

激酶抑制剂 BKI-1708 干扰胞质分裂并驱动包囊形成顶复门寄生虫弓形虫、犬新孢子虫和贝氏贝氏虫的重殖子转化

de Sousa, Maria Cristina Ferreira; Müller, Joachim; Hänggeli, Kai Pascal Alexander; Heller, Manfred; Uldry, Anne-Christine; Braga-Lagache, Sophie; Leitao, Alexandre; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; Van Voorhis, Wesley C; Hemphill, Andrew

Treatment with BKI-1748 after Toxoplasma gondii systemic dissemination in experimentally infected pregnant sheep improves fetal and lamb mortality and morbidity and prevents congenital infection.

在实验感染弓形虫的怀孕绵羊体内发生全身性播散后,用 BKI-1748 进行治疗可改善胎儿和羔羊的死亡率和发病率,并预防先天性感染

Sánchez-Sánchez Roberto, Huertas-López Ana, Largo-de la Torre Andrea, Ferre Ignacio, Dini Filippo Maria, Re Michela, Moreno-Gonzalo Javier, Choi Ryan, Hulverson Matthew A, Ojo Kayode K, Arnold Samuel L M, Hemphill Andrew, Van Voorhis Wesley C, Ortega-Mora Luis Miguel

Norditerpene Natural Products from Subterranean Fungi with Anti-Parasitic Activity

具有抗寄生虫活性的地下真菌来源的北二萜类天然产物

Kolas, Alexandra; Rusman, Yudi; Maia, Ana C R G; Williams, Jessica M; Xie, Jiashu; Katekar, Roshan; Fumuso, Fernanda G; Cotto-Rosario, Alexis; Onoh, Chidiebere N; Baggar, Hanen; Piaskowski, Mary L; Baigorria, Christian; Paes, Raphaella; Chakrabarti, Debopam; Weible, Lyssa J; Ojo, Kayode K; O'Connor, Roberta M; Salomon, Christine E

Bumped Kinase Inhibitors Inhibit both Toxoplasma gondii MAPKL1 and CDPK1

激酶抑制剂可同时抑制弓形虫 MAPKL1 和 CDPK1。

Montgomery, Jemma A; Alday, P Holland; Choi, Ryan; Khim, Monique; Staker, Bart L; Hulverson, Matthew A; Ojo, Kayode K; Fan, Erkang; Van Voorhis, Wesley C; Doggett, J Stone

Versatile Imidazole Scaffold with Potent Activity against Multiple Apicomplexan Parasites.

多功能咪唑骨架,对多种顶复门寄生虫具有强效活性

Khim Monique, Montgomery Jemma, Laureano De Souza Mariana, Delvillar Melvin, Weible Lyssa J, Prabakaran Mayuri, Hulverson Matthew A, Eck Tyler, Bheemanabonia Rammohan Y, Alday P Holland, Rotella David P, Doggett J Stone, Staker Bart L, Ojo Kayode K, Bhanot Purnima

Anti-Cryptosporidium efficacy of BKI-1708, an inhibitor of Cryptosporidium calcium-dependent protein kinase 1

BKI-1708(一种隐孢子虫钙依赖性蛋白激酶1抑制剂)的抗隐孢子虫功效

Choi, Ryan; Hulverson, Matthew A; Schaefer, Deborah A; Betzer, Dana P; Riggs, Michael W; Huang, Wenlin; Sun, Vicky; Whitman, Grant R; McCloskey, Molly C; Marsh, Kennan; Buck, Wayne R; Wagner, David S; Yang, Junhai; Bowman, Andrew P; Ciurlionis, Rita; Ajiboye, Jubilee; Hemphill, Andrew; Sigalapalli, Dilep K; Arnold, Samuel L M; Barrett, Lynn K; Ojo, Kayode K; Fan, Erkang; Van Voorhis, Wesley C

Norditerpene natural products from subterranean fungi with anti-parasitic activity

具有抗寄生虫活性的地下真菌来源的北二萜类天然产物

Kolas, Alexandra; Rusman, Yudi; Maia, Ana C G; Williams, Jessica; Fumuso, Fernanda G; Cotto-Rosario, Alexis; Onoh, Chidiebere; Baggar, Hanen; Piaskowski, Mary L; Baigorria, Christian; Paes, Raphaella; Chakrabarti, Debopam; Weible, Lyssa; Ojo, Kayode K; O'Connor, Roberta M; Salomon, Christine E

A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

一种抑制前列腺癌糖酵解的化合物可控制晚期前列腺癌的生长

Takuma Uo ,Kayode K Ojo ,Cynthia C T Sprenger ,Kathryn S Epilepsia ,B Gayani K Perera ,Mamatha Damodarasamy ,Shihua Sun ,Soojin Kim ,Hannah H Hogan ,Matthew A Hulverson ,Ryan Choi ,Grant R Whitman ,Lynn K Barrett ,Samantha A Michaels ,Linda H Xu ,Vicky L Sun ,Samuel L M Arnold ,Haley J Pang ,Matthew M Nguyen ,Anna-Lena B G Vigil ,Varun Kamat ,Lucas B Sullivan ,Ian R Sweet ,Ram Vidadala ,Dustin J Maly ,Wesley C Van Voorhis ,Stephen R Plymate

An Early Treatment With BKI-1748 Exhibits Full Protection Against Abortion and Congenital Infection in Sheep Experimentally Infected With Toxoplasma gondii

对实验感染弓形虫的绵羊进行早期BKI-1748治疗,可完全预防流产和先天性感染。

Sánchez-Sánchez, Roberto; Imhof, Dennis; Hecker, Yanina P; Ferre, Ignacio; Re, Michela; Moreno-Gonzalo, Javier; Blanco-Murcia, Javier; Mejías-López, Elena; Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Ojo, Kayode K; Barrett, Lynn K; Hemphill, Andrew; Van Voorhis, Wesley C; Ortega-Mora, Luis Miguel

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

一种抑制前列腺癌糖酵解的化合物可控制晚期前列腺癌的生长

Uo, Takuma; Ojo, Kayode K; Sprenger, Cynthia C; Epilepsia, Kathryn Soriano; Perera, B Gayani K; Damodarasamy, Mamatha; Sun, Shihua; Kim, Soojin; Hogan, Hannah H; Hulverson, Matthew A; Choi, Ryan; Whitman, Grant R; Barrett, Lynn K; Michaels, Samantha A; Xu, Linda H; Sun, Vicky L; Arnold, Samuel L M; Pang, Haley J; Nguyen, Matthew M; Vigil, Anna-Lena B G; Kamat, Varun; Sullivan, Lucas B; Sweet, Ian R; Vidadala, Ram; Maly, Dustin J; Van Voorhis, Wesley C; Plymate, Stephen R