文献库，生知库 | 链接生命科学的每一步

Yoon Yongdae, Sharma Lokesh, Tang Wenwen, Kirk Shannon, Raredon Micha Sam Brickman, Ahangari Farida, Khoury Johad, Qian Hong, Ke Yunbo, Tulapurkar Mohan, Liu Ruya, Luan Yi, Yuan Qianying, Chen Lujia, Birukov Konstantin, Simons Michael, Wu Dianqing, Niklason Laura E, Kaminski Naftali, Yuan Yifan

心血管

发表日期：2026

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Inhibition of proton sensor GPR68 suppresses endothelial dysfunction and acute lung injury caused by Staphylococcus aureus bacterial particles

抑制质子传感器GPR68可抑制金黄色葡萄球菌颗粒引起的内皮功能障碍和急性肺损伤。

期刊:FASEB Journal

影响因子:4.2

doi:10.1096/fj.202401947R

Karki, Pratap; Ke, Yunbo; Zhang, Chen-Ou; Promnares, Kamoltip; Li, Yue; Williams, Charles H; Hong, Charles C; Birukov, Konstantin G; Birukova, Anna A

发表日期：2025

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Novel small molecule inhibitor of GPR68 attenuates endothelial dysfunction and lung injury caused by bacterial lipopolysaccharide

新型GPR68小分子抑制剂可减轻细菌脂多糖引起的内皮功能障碍和肺损伤

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-02582-y

Karki, Pratap; Ke, Yunbo; Zhang, Chen-Ou; Promnares, Kamoltip; Li, Yue; Williams, Charles H; Birukov, Konstantin G; Hong, Charles C; Birukova, Anna A

微生物学

发表日期：2025

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GPR68 Mediates Lung Endothelial Dysfunction Caused by Bacterial Inflammation and Tissue Acidification

GPR68介导细菌炎症和组织酸化引起的肺内皮功能障碍

期刊:Cells

影响因子:5.2

doi:10.3390/cells13242125

Karki, Pratap; Ke, Yunbo; Zhang, Chenou; Promnares, Kamoltip; Li, Yue; Williams, Charles H; Hong, Charles C; Birukov, Konstantin G; Birukova, Anna A

Immunology/Inflammation

发表日期：2024

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Class B Scavenger Receptor CD36 as a Potential Therapeutic Target in Inflammation Induced by Danger-Associated Molecular Patterns

B类清道夫受体CD36作为危险相关分子模式诱导炎症的潜在治疗靶点

期刊:Cells

影响因子:5.2

doi:10.3390/cells13231992

Baranova, Irina N; Bocharov, Alexander V; Vishnyakova, Tatyana G; Chen, Zhigang; Ke, Yunbo; Birukova, Anna A; Yuen, Peter S T; Tsuji, Takayuki; Star, Robert A; Birukov, Konstantin G; Patterson, Amy P; Eggerman, Thomas L

Immunology/Inflammation

CD3

发表日期：2024

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NLRP3 regulates immunometabolism, impacting microglial function in Alzheimer’s disease

NLRP3调节免疫代谢，影响阿尔茨海默病中的小胶质细胞功能

期刊:

影响因子:

doi:10.1101/2024.12.16.628787

Yuan, Yifan; Sharma, Lokesh; Tang, Wenwen; Yoon, Yongdae; Kirk, Shannon; Raredon, Micha Sam Brickman; Ahangari, Farida; Khoury, Johad; Hong, Qian; Luan, Yi; Yuan, Qianying; Lujia, Chen; Ke, Yunbo; Birukov, Konstantin G; Simons, Michael; Wu, Dianqing Dan; Niklason, Laura E; Kaminski, Naftali; McManus, Roisin M; Komes, Max P; Griep, Angelika; Santarelli, Francesco; Schwartz, Stephanie; Perea, Juan; Khalil, Michelle‐Amirah; Schlachetzki, Johannes CM; Bouvier, David S; Lauterbach, Mario; Schmidt, Susanne V; Gomez‐Cabrero, David; Tegner, Jesper; Glass, Christopher K; Hiller, Karsten; Latz, Eicke; Heneka, Michael T

Circulating extracellular histones exacerbate acute lung injury by augmenting pulmonary endothelial dysfunction via TLR4-dependent mechanism

循环中的细胞外组蛋白通过TLR4依赖性机制加剧肺内皮功能障碍，从而加重急性肺损伤。

期刊:American Journal of Physiology-Lung Cellular and Molecular Physiology

影响因子:3.5

doi:10.1152/ajplung.00072.2022

Kim, Junghyun; Baalachandran, Ramasubramanian; Li, Yue; Zhang, Chen-Ou; Ke, Yunbo; Karki, Pratap; Birukov, Konstantin G; Birukova, Anna A

Erratum for Baranova et al., "Class B Scavenger Receptors BI and BII Protect against LPS-Induced Acute Lung Injury in Mice by Mediating LPS Clearance"

Baranova 等人的论文“B 类清道夫受体 BI 和 BII 通过介导 LPS 清除来保护小鼠免受 LPS 诱导的急性肺损伤”的勘误

期刊:Infection and Immunity

影响因子:2.8

doi:10.1128/iai.00404-22

Baranova, Irina N; Bocharov, Alexander V; Vishnyakova, Tatyana G; Chen, Zhigang; Birukova, Anna A; Ke, Yunbo; Hu, Xuzhen; Yuen, Peter S T; Star, Robert A; Birukov, Konstantin G; Patterson, Amy P; Eggerman, Thomas L

信号转导

发表日期：2022

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Staphylococcus aureus-induced endothelial permeability and inflammation are mediated by microtubule destabilization.

金黄色葡萄球菌引起的内皮通透性和炎症是由微管不稳定介导的

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.RA118.004030

Karki Pratap, Ke Yunbo, Tian Yufeng, Ohmura Tomomi, Sitikov Albert, Sarich Nicolene, Montgomery Christopher P, Birukova Anna A

Mechanosensitive Rap1 activation promotes barrier function of lung vascular endothelium under cyclic stretch.

机械敏感性 Rap1 激活促进肺血管内皮在周期性拉伸下的屏障功能

期刊:Molecular Biology of the Cell

影响因子:2.7

doi:10.1091/mbc.E18-07-0422

Ke Yunbo, Karki Pratap, Zhang Chenou, Li Yue, Nguyen Trang, Birukov Konstantin G, Birukova Anna A

Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury.

血管内皮生长因子-D可改善急性肺损伤期间的肺血管完整性。

Inhibition of proton sensor GPR68 suppresses endothelial dysfunction and acute lung injury caused by Staphylococcus aureus bacterial particles

抑制质子传感器GPR68可抑制金黄色葡萄球菌颗粒引起的内皮功能障碍和急性肺损伤。

Novel small molecule inhibitor of GPR68 attenuates endothelial dysfunction and lung injury caused by bacterial lipopolysaccharide

新型GPR68小分子抑制剂可减轻细菌脂多糖引起的内皮功能障碍和肺损伤

GPR68 Mediates Lung Endothelial Dysfunction Caused by Bacterial Inflammation and Tissue Acidification

GPR68介导细菌炎症和组织酸化引起的肺内皮功能障碍

Class B Scavenger Receptor CD36 as a Potential Therapeutic Target in Inflammation Induced by Danger-Associated Molecular Patterns

B类清道夫受体CD36作为危险相关分子模式诱导炎症的潜在治疗靶点

NLRP3 regulates immunometabolism, impacting microglial function in Alzheimer’s disease

NLRP3调节免疫代谢，影响阿尔茨海默病中的小胶质细胞功能

Circulating extracellular histones exacerbate acute lung injury by augmenting pulmonary endothelial dysfunction via TLR4-dependent mechanism

循环中的细胞外组蛋白通过TLR4依赖性机制加剧肺内皮功能障碍，从而加重急性肺损伤。

Erratum for Baranova et al., "Class B Scavenger Receptors BI and BII Protect against LPS-Induced Acute Lung Injury in Mice by Mediating LPS Clearance"

Baranova 等人的论文“B 类清道夫受体 BI 和 BII 通过介导 LPS 清除来保护小鼠免受 LPS 诱导的急性肺损伤”的勘误

Staphylococcus aureus-induced endothelial permeability and inflammation are mediated by microtubule destabilization.

金黄色葡萄球菌引起的内皮通透性和炎症是由微管不稳定介导的

Mechanosensitive Rap1 activation promotes barrier function of lung vascular endothelium under cyclic stretch.

机械敏感性 Rap1 激活促进肺血管内皮在周期性拉伸下的屏障功能