Keatinge-Clay Adrian T相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Serendipity and the Slime Mold: A Visual Survey of High-Molecular-Weight Protein Assemblies Reveals the Structure of the Polyketide Synthase Pks16

意外发现与黏菌：高分子量蛋白质组装体的可视化调查揭示了聚酮合酶 Pks16 的结构

期刊:Molecular & Cellular Proteomics

影响因子:5.5

doi:10.1016/j.mcpro.2025.101484

Hoogerbrugge, Gabriel; Keatinge-Clay, Adrian T; Marcotte, Edward M

发表日期：2026

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A CRISPR-Cas9 system for knock-out and knock-in of high molecular weight DNA enables module-swapping of the pikromycin synthase in its native host

利用 CRISPR-Cas9 系统敲除和敲入高分子量 DNA，可以实现匹克罗霉素合酶在其天然宿主中的模块交换。

期刊:Microbial Cell Factories

影响因子:4.9

doi:10.1186/s12934-025-02741-w

Wang, Zhe-Chong; Stegall, Hayden; Miyazawa, Takeshi; Keatinge-Clay, Adrian T

发表日期：2025

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A CRISPR-Cas9 System for Knock-out and Knock-in of High Molecular Weight DNA Enables Module-Swapping of the Pikromycin Synthase in its Native Host

利用 CRISPR-Cas9 系统敲除和敲入高分子量 DNA，可实现匹克罗霉素合成酶在其天然宿主中的模块交换

doi:10.21203/rs.3.rs-6229288/v1

Wang, Zhe-Chong; Stegall, Hayden; Miyazawa, Takeshi; Keatinge-Clay, Adrian T

发表日期：2025

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Modular polyketide synthase ketosynthases collaborate with upstream dehydratases to install double bonds

模块化聚酮合酶酮合成酶与上游脱水酶协同作用，形成双键。

期刊:Chemical Communications

影响因子:4.2

doi:10.1039/d4cc03034f

Ray, Katherine A; Saif, Nisha; Keatinge-Clay, Adrian T

发表日期：2024

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Mutagenesis Supports AlphaFold Prediction of How Modular Polyketide Synthase Acyl Carrier Proteins Dock With Downstream Ketosynthases

诱变实验支持 AlphaFold 对模块化聚酮合酶酰基载体蛋白如何与下游酮合酶对接的预测。

期刊:Proteins-Structure Function and Bioinformatics

影响因子:2.8

doi:10.1002/prot.26733

Hirsch, Melissa; Desai, Ronak R; Annaswamy, Shreyas; Keatinge-Clay, Adrian T

发表日期：2024

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Boosting titers of engineered triketide and tetraketide synthases to record levels through T7 promoter tuning

通过T7启动子调控，将工程化三酮和四酮合酶的滴度提升至历史新高。

期刊:Metabolic Engineering

影响因子:6.8

doi:10.1016/j.ymben.2023.05.008

Zhang, Jie; Bista, Ramesh; Miyazawa, Takeshi; Keatinge-Clay, Adrian T

发表日期：2023

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Determination of Enantiomeric Excess and Diastereomeric Excess via Optical Methods. Application to α-methyl-β-hydroxy-carboxylic acids

利用光学方法测定对映体过量和非对映体过量。以α-甲基-β-羟基羧酸为例

doi:10.1039/d2qo01444k

Moor, Sarah R; Howard, James R; Herrera, Brenden T; McVeigh, Matthew S; Marini, Federico; Keatinge-Clay, Adrian T; Anslyn, Eric V

发表日期：2023

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Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.

来自匹克罗霉素合成酶的启动酶揭示了装配线酮合成酶如何催化碳-碳化学反应

期刊:Structure

影响因子:4.3

doi:10.1016/j.str.2022.05.021

Dickinson Miles S, Miyazawa Takeshi, McCool Ryan S, Keatinge-Clay Adrian T

发表日期：2022

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Functional Studies and Revision of the NFAT-133/TM-123 Biosynthetic Pathway in Streptomyces pactum

链霉菌中NFAT-133/TM-123生物合成途径的功能研究与修订

期刊:ACS Chemical Biology

影响因子:3.8

doi:10.1021/acschembio.2c00454

Zhou, Wei; Alharbi, Hattan A; Hummingbird, Eshe; Keatinge-Clay, Adrian T; Mahmud, Taifo

发表日期：2022

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Evidence for an Enzyme-Catalyzed Rauhut-Currier Reaction during the Biosynthesis of Spinosyn A

棘霉素A生物合成过程中酶催化Rauhut-Currier反应的证据

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.1c09482

Choi, Sei-Hyun; Jeon, Byungsun; Kim, Namho; Wu, Hsin-Hui; Ko, Tzu-Ping; Ruszczycky, Mark W; Isiorho, Eta A; Liu, Yung-Nan; Keatinge-Clay, Adrian T; Tsai, Ming-Daw; Liu, Hung-Wen

发表日期：2021

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