日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Humanized mouse models for immuno-oncology research

用于免疫肿瘤学研究的人源化小鼠模型

Chuprin, Jane; Buettner, Hannah; Seedhom, Mina O; Greiner, Dale L; Keck, James G; Ishikawa, Fumihiko; Shultz, Leonard D; Brehm, Michael A

Enhanced development of functional human NK cells in NOD-scid-IL2rg(null) mice expressing human IL15.

在表达人IL15的NOD-scid-IL2rg(null)小鼠中增强了功能性人NK细胞的发育

Aryee Ken-Edwin, Burzenski Lisa M, Yao Li-Chin, Keck James G, Greiner Dale L, Shultz Leonard D, Brehm Michael A

Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection

人源化小鼠的克里米亚-刚果出血热揭示神经胶质细胞是神经系统感染的主要靶点

Spengler, Jessica R; Kelly Keating, M; McElroy, Anita K; Zivcec, Marko; Coleman-McCray, JoAnn D; Harmon, Jessica R; Bollweg, Brigid C; Goldsmith, Cynthia S; Bergeron, Éric; Keck, James G; Zaki, Sherif R; Nichol, Stuart T; Spiropoulou, Christina F

Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver

感染埃博拉病毒或雷斯顿病毒的人源化小鼠的疾病严重程度与肝脏早期病毒复制的程度相关

Spengler, Jessica R; Saturday, Greg; Lavender, Kerry J; Martellaro, Cynthia; Keck, James G; Nichol, Stuart T; Spiropoulou, Christina F; Feldmann, Heinz; Prescott, Joseph

Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment

在表达转基因以支持人类髓系和淋巴系细胞移植的小鼠中,埃博拉病毒复制和疾病发生而不出现免疫病理学症状

Spengler, Jessica R; Lavender, Kerry J; Martellaro, Cynthia; Carmody, Aaron; Kurth, Andreas; Keck, James G; Saturday, Greg; Scott, Dana P; Nichol, Stuart T; Hasenkrug, Kim J; Spiropoulou, Christina F; Feldmann, Heinz; Prescott, Joseph

Bridging tumor genomics to patient outcomes through an integrated patient-derived xenograft platform

通过整合的患者来源异种移植平台,将肿瘤基因组学与患者预后联系起来

Gandara, David R; Mack, Philip C; Bult, Carol; Li, Tianhong; Lara, Primo N Jr; Riess, Jonathan W; Astrow, Stephanie H; Gandour-Edwards, Regina; Cooke, David T; Yoneda, Ken Y; Moore, Elizabeth H; Pan, Chong-Xian; Burich, Rebekah A; David, Elizabeth A; Keck, James G; Airhart, Susan; Goodwin, Neal; de Vere White, Ralph W; Liu, Edison T

Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

一项针对骨髓增生异常综合征患者的新型谷胱甘肽类似物前药——盐酸依扎替司他脂质体注射剂(Telintra,TLK199)的1-2a期多中心剂量递增研究

Raza, Azra; Galili, Naomi; Callander, Natalie; Ochoa, Leonel; Piro, Lawrence; Emanuel, Peter; Williams, Stephanie; Burris, Howard 3rd; Faderl, Stefan; Estrov, Zeev; Curtin, Peter; Larson, Richard A; Keck, James G; Jones, Marsha; Meng, Lisa; Brown, Gail L