The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6.

Stat3 的卷曲螺旋结构域对于其 SH2 结构域介导的受体结合以及随后由表皮生长因子和白细胞介素-6 诱导的激活至关重要