日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Orchestrating function: Concerted dynamics, allostery, and catalysis in protein tyrosine phosphatases

协调功能:蛋白质酪氨酸磷酸酶中的协同动力学、变构和催化作用

Woods, Virgil A; Sharma, Shivani; Lemberikman, Alexis M; Keedy, Daniel A

Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction

酪氨酸磷酸酶 PTP1B 通过蛋白质-蛋白质相互作用进行变构调节

Chartier, Cassandra A; Woods, Virgil A; Xu, Yunyao; van Vlimmeren, Anne E; Johns, Andrew C; Jovanovic, Marko; McDermott, Ann E; Keedy, Daniel A; Shah, Neel H

Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites.

人类蛋白酪氨酸磷酸酶变体的结构揭示了可靶向的变构位点。

Perdikari Aliki, Woods Virgil A, Ebrahim Ali, Lawler Katherine, Bounds Rebecca, Shah Dinesh S, Singh Nathanael I, Mehlman Tamar Skaist, Riley Blake T, Sharma Shivani, Morris Jackson W, Keogh Julia M, Henning Elana, Smith Miriam, Farooqi I Sadaf, Keedy Daniel A

Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models

利用晶体学多构象模型集合绘制相关蛋白质结构中的变构重连图

Raju, Akshay; Sharma, Shivani; Riley, Blake T; Djuraev, Shakhriyor; Tan, Yingxian; Kim, Minyoung; Mahmud, Toufique; Keedy, Daniel A

Structure-Based Experimental Datasets for Benchmarking Protein Simulation Force Fields [Article v1.0]

用于蛋白质模拟力场基准测试的基于结构的实验数据集 [文章 v1.0]

Cavender, Chapin E; Case, David A; Chen, Julian C-H; Chong, Lillian T; Keedy, Daniel A; Lindorff-Larsen, Kresten; Mobley, David L; Ollila, O H Samuli; Oostenbrink, Chris; Robustelli, Paul; Voelz, Vincent A; Wall, Michael E; Wych, David C; Gilson, Michael K

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.

人类 PTP1B 变体的结构揭示了可作为减肥疗法靶点的变构位点

Perdikari Aliki, Woods Virgil A, Ebrahim Ali, Lawler Katherine, Bounds Rebecca, Singh Nathanael I, Mehlman Tamar Skaist, Riley Blake T, Sharma Shivani, Morris Jackson W, Keogh Julia M, Henning Elana, Smith Miriam, Farooqi I Sadaf, Keedy Daniel A

Automated multiconformer model building for X-ray crystallography and cryo-EM

用于X射线晶体学和冷冻电镜的自动化多构象模型构建

Wankowicz, Stephanie A; Ravikumar, Ashraya; Sharma, Shivani; Riley, Blake; Raju, Akshay; Hogan, Daniel W; Flowers, Jessica; van den Bedem, Henry; Keedy, Daniel A; Fraser, James S

Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS

利用高分辨率HDX-MS探测PTP1B的天然动力学和变构反应

Woods, Virgil A; Abzalimov, Rinat R; Keedy, Daniel A

Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP

极端条件:高温和高压对STEP结构的不同影响

Guerrero, Liliana; Ebrahim, Ali; Riley, Blake T; Kim, Minyoung; Huang, Qingqiu; Finke, Aaron D; Keedy, Daniel A

An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data

通过对大规模晶体学数据进行计算重新分析,获得了变构酶 PTP1B 的片段结合结构扩展库。

Mehlman, Tamar; Ginn, Helen M; Keedy, Daniel A