Keefe T相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Correction: INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors

更正：INX-315，一种选择性 CDK2 抑制剂，可诱导实体瘤细胞周期停滞和衰老。

期刊:Cancer Discovery

影响因子:33.3

doi:10.1158/2159-8290.CD-25-1502

Dietrich, Catherine; Trub, Alec; Ahn, Antonio; Taylor, Michael; Ambani, Krutika; Chan, Keefe T; Lu, Kun-Hui; Mahendra, Christabella A; Blyth, Catherine; Coulson, Rhiannon; Ramm, Susanne; Watt, April C; Matsa, Sunil Kumar; Bisi, John; Strum, Jay; Roberts, Patrick; Goel, Shom

细胞生物学

发表日期：2025

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Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer.

利用铁稳态失调来根除顽固性高级别浆液性卵巢癌

期刊:Cell Death Discovery

doi:10.1038/s41420-025-02716-1

Cerra Carmelo, Tancock Madeleine R C, Thio Niko, Koo Ada, Wong AnnRann, J Cowley Karla, Varshney Swati, Willis Madelynne O, Simpson Kaylene J, Bowtell David D L, Sanij Elaine, Christie Elizabeth L, Pearson Richard B, Kang Jian, Chan Keefe T

发表日期：2025

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INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors

INX-315 是一种选择性 CDK2 抑制剂，可诱导实体瘤细胞周期停滞和衰老。

期刊:Cancer Discovery

影响因子:29.7

doi:10.1158/2159-8290.CD-23-0954

Catherine Dietrich # ，Alec Trub # ，Antonio Ahn ，Michael Taylor ，Krutika Ambani ，Keefe T Chan ，Kun-Hui Lu ，Christabella A Mahendra ，Catherine Blyth ，Rhiannon Coulson ，Susanne Ramm ，April C Watt ，Sunil Kumar Matsa ，John Bisi ，Jay Strum ，Patrick Roberts ，Shom Goel

细胞生物学

发表日期：2024

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Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

胱硫醚-β-合酶是 AKT 诱导的衰老所必需的，并通过 PI3K/AKT 激活抑制胃癌的发展

影响因子:6.4

doi:10.7554/eLife.71929

Haoran Zhu #, Keefe T Chan #, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna S Trigos, Dovile Anderson, Darren J Creek, David P De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B Pearson, Jian Kang

发表日期：2022

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The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

RNA 聚合酶 I 转录抑制剂 CX-5461 与拓扑异构酶 1 抑制协同作用，增强同源重组功能正常的高级别浆液性卵巢癌中的 DNA 损伤反应

期刊:British Journal of Cancer

影响因子:6.4

doi:10.1038/s41416-020-01158-z

Shunfei Yan, Jiachen Xuan, Natalie Brajanovski, Madeleine R C Tancock, Piyush B Madhamshettiwar, Kaylene J Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Elaine Sanij #, Richard B Pearson #, Keefe T Chan #

发表日期：2021

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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

CX-5461 激活 DNA 损伤反应并证明对高级别浆液性卵巢癌具有治疗作用

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-020-16393-4

Elaine Sanij #, Katherine M Hannan #, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J

发表日期：2020

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A functional genetic screen defines the AKT-induced senescence signaling network

功能性遗传筛选确定了 AKT 诱导的衰老信号网络

期刊:Cell Death and Differentiation

影响因子:13.7

doi:10.1038/s41418-019-0384-8

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson5

细胞生物学

发表日期：2020

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Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

重新编程的mRNA翻译驱动对核糖体生物合成治疗靶向性的抵抗

期刊:EMBO Journal

影响因子:9.4

doi:10.15252/embj.2020105111

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan #, Jian Kang #, Richard B Pearson #

发表日期：2020

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Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

PRMT5-MDM4 轴的调节对于黑色素瘤对 CDK4/6 抑制剂的反应至关重要

期刊:Proceedings of the National Academy of Sciences of the United States of America

doi:10.1073/pnas.1901323116

Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Gho

发表日期：2019

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Cystathionine β-Synthase in Physiology and Cancer

胱硫醚β-合成酶在生理学和癌症中的作用

期刊:Biomed Research International

影响因子:2.3

doi:10.1155/2018/3205125

Zhu, Haoran; Blake, Shaun; Chan, Keefe T; Pearson, Richard B; Kang, Jian

发表日期：2018

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