日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors

INX-315 是一种选择性 CDK2 抑制剂,可诱导实体瘤细胞周期停滞和衰老。

Catherine Dietrich # ,Alec Trub # ,Antonio Ahn ,Michael Taylor ,Krutika Ambani ,Keefe T Chan ,Kun-Hui Lu ,Christabella A Mahendra ,Catherine Blyth ,Rhiannon Coulson ,Susanne Ramm ,April C Watt ,Sunil Kumar Matsa ,John Bisi ,Jay Strum ,Patrick Roberts ,Shom Goel

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

胱硫醚-β-合酶是 AKT 诱导的衰老所必需的,并通过 PI3K/AKT 激活抑制胃癌的发展

Haoran Zhu #, Keefe T Chan #, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna S Trigos, Dovile Anderson, Darren J Creek, David P De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B Pearson, Jian Kang

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

RNA 聚合酶 I 转录抑制剂 CX-5461 与拓扑异构酶 1 抑制协同作用,增强同源重组功能正常的高级别浆液性卵巢癌中的 DNA 损伤反应

Shunfei Yan, Jiachen Xuan, Natalie Brajanovski, Madeleine R C Tancock, Piyush B Madhamshettiwar, Kaylene J Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Elaine Sanij #, Richard B Pearson #, Keefe T Chan #

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

CX-5461 激活 DNA 损伤反应并证明对高级别浆液性卵巢癌具有治疗作用

Elaine Sanij #, Katherine M Hannan #, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J

A functional genetic screen defines the AKT-induced senescence signaling network

功能性遗传筛选确定了 AKT 诱导的衰老信号网络

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson5

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

重新编程的mRNA翻译驱动对核糖体生物合成治疗靶向性的抵抗

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan #, Jian Kang #, Richard B Pearson #

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

PRMT5-MDM4 轴的调节对于黑色素瘤对 CDK4/6 抑制剂的反应至关重要

Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Gho

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

CX-5461 抑制 RNA 聚合酶 I 转录起始可激活非典型 ATM/ATR 信号

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, El

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

IL2 诱导性 T 细胞激酶,黑色素瘤的新型治疗靶点

Craig C Carson, Stergios J Moschos, Sharon N Edmiston, David B Darr, Nana Nikolaishvili-Feinberg, Pamela A Groben, Xin Zhou, Pei Fen Kuan, Shaily Pandey, Keefe T Chan, Jamie L Jordan, Honglin Hao, Jill S Frank, Dennis A Hopkinson, David C Gibbs, Virginia D Alldredge, Eloise Parrish, Sara C Hanna, Pa

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

β2-肾上腺素能受体信号调节侵袭性伪足形成以增强肿瘤细胞侵袭

Sarah J Creed, Caroline P Le, Mona Hassan, Cindy K Pon, Sabine Albold, Keefe T Chan, Matthew E Berginski, Zhendong Huang, James E Bear, J Robert Lane, Michelle L Halls, Davide Ferrari, Cameron J Nowell, Erica K Sloan