日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Rationally Designed AAV9-DM Capsid with Minimal Liver Tropism

一种经过合理设计的、肝脏趋向性极低的AAV9-DM衣壳

Nabakowski, Zoe C; Jaramillo, Izabella C; Tanachaiwiwat, Primrose; Keeler, Geoffrey D

Fecal AAV8 shedding and co-housing reduces EAE disease severity: implications for preclinical study design

粪便中AAV8的排出和共同饲养可降低EAE疾病的严重程度:对临床前研究设计的启示

Gaddie, Cristina D; Keeler, Geoffrey D

Enhanced transgene expression from single-stranded AAV vectors in human cells in vitro and in murine hepatocytes in vivo.

单链 AAV 载体在体外人类细胞和体内小鼠肝细胞中增强转基因表达

Lu Yuan, Ling Chen, Shoti Jakob, Yang Hua, Nath Aneesha, Keeler Geoffrey D, Qing Keyun, Srivastava Arun

Rational Design of AAV-rh74, AAV3B, and AAV8 with Limited Liver Targeting

合理设计靶向肝脏有限的AAV-rh74、AAV3B和AAV8

Chan, Christopher; Harris, Kathryn K; Zolotukhin, Sergei; Keeler, Geoffrey D

AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo

AAV3-miRNA载体可抑制体外培养的人肝细胞癌细胞生长以及体内小鼠异种移植模型中的人肝肿瘤生长。

Yin, Ling; Keeler, Geoffrey D; Zhang, Yuanhui; Hoffman, Brad E; Ling, Chen; Qing, Keyun; Srivastava, Arun

Type I IFN Sensing by cDCs and CD4(+) T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8(+) T Cells

cDC对I型干扰素的感知以及CD4(+) T细胞的辅助对于AAV衣壳特异性CD8(+) T细胞的交叉启动都是必需的

Shirley, Jamie L; Keeler, Geoffrey D; Sherman, Alexandra; Zolotukhin, Irene; Markusic, David M; Hoffman, Brad E; Morel, Laurence M; Wallet, Mark A; Terhorst, Cox; Herzog, Roland W

Liver induced transgene tolerance with AAV vectors

利用AAV载体诱导肝脏转基因耐受性

Keeler, Geoffrey D; Markusic, David M; Hoffman, Brad E

Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis

基因治疗诱导的抗原特异性调节性T细胞抑制神经炎症并逆转多发性硬化症小鼠模型中的疾病

Keeler, Geoffrey D; Kumar, Sandeep; Palaschak, Brett; Silverberg, Emily L; Markusic, David M; Jones, Noah T; Hoffman, Brad E