日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanisms of clinical resistance to selective FGFR2 inhibition by lirafugratinib.

利拉夫替尼选择性抑制FGFR2的临床耐药机制。

Ellis H, Balasooriya E R, Varkaris A, Hajian B, Wan J, Shekhar M, Gritti I, Vijay V, Albertelli L, Piot S, Lau K, Kehlmann A, Chevalier N, Nugent F W, Zhen Y, Silveira V S, Sellers W R, Corcoran R B, Juric D, Bardeesy N

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

变构 PI3Kα 抑制剂可克服由继发性 PIK3CA 突变介导的对正构抑制剂的靶向耐药性

Andreas Varkaris #, Ferran Fece de la Cruz #, Elizabeth E Martin #, Bryanna L Norden, Nicholas Chevalier, Allison M Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P Danysh, Laxmi

Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment

受压的靶癌细胞驱动CAR T细胞和实体瘤微环境的非基因重编程

Yufeng Wang ,David L Drum ,Ruochuan Sun ,Yida Zhang ,Feng Chen ,Fengfei Sun ,Emre Dal ,Ling Yu ,Jingyu Jia ,Shahrzad Arya ,Lin Jia ,Song Fan ,Steven J Isakoff ,Allison M Kehlmann ,Gianpietro Dotti ,Fubao Liu ,Hui Zheng ,Cristina R Ferrone ,Alphonse G Taghian ,Albert B DeLeo ,Marco Ventin ,Giulia Cattaneo ,Yongxiang Li ,Youssef Jounaidi ,Peigen Huang ,Cristina Maccalli ,Hanyu Zhang ,Cheng Wang ,Jibing Yang ,Genevieve M Boland ,Ruslan I Sadreyev ,LaiPing Wong ,Soldano Ferrone ,Xinhui Wang

Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and tumor microenvironment, overcoming multiple obstacles of CAR T therapy for solid tumors

应激靶癌细胞驱动CAR-T细胞和肿瘤微环境的非基因重编程,攻克CAR-T治疗实体肿瘤的多重障碍

Yufeng Wang, David L Drum, Ruochuan Sun, Yida Zhang, Ling Yu, Lin Jia, Steven J Isakoff, Allison M Kehlmann, Ali Emre Dal, Gianpietro Dotti, Hui Zheng, Cristina R Ferrone, Alphonse G Taghian, Albert B DeLeo, Hanyu Zhang, Youssef Jounaidi, Song Fan, Peigen Huang, Cheng Wang, Jibing Yang, Genevieve M

An Initial Evaluation of Human Plasma cMLC-1: A Potential Protein Biomarker for Trastuzumab-Induced Cardiotoxicity, Breast Cancer Screening and Progression

人类血浆 cMLC-1 的初步评估:曲妥珠单抗诱发的心脏毒性、乳腺癌筛查和进展的潜在蛋白质生物标志物

Ling Yu, Read Allen, Lin Jia, Ting Sun, Steven J Isakoff, Marielle Scherrer-Crosbie, Allison M Kehlmann, Hui Zheng, Amy Ly, Charlotte S Walmsley, Katherine Hesler, Ava N Varasteh, Christopher J Pinto, Daniel E McLoughlin, Wenjin Wu, Xinhui Wang

Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea

阻塞性睡眠呼吸暂停患者呼吸觉醒阈值的临床预测因素

Edwards, Bradley A; Eckert, Danny J; McSharry, David G; Sands, Scott A; Desai, Amar; Kehlmann, Geoffrey; Bakker, Jessie P; Genta, Pedro R; Owens, Robert L; White, David P; Wellman, Andrew; Malhotra, Atul

Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold

艾司佐匹克隆可提高低觉醒阈值阻塞性睡眠呼吸暂停患者的呼吸觉醒阈值,并降低其呼吸暂停/低通气指数。

Eckert, Danny J; Owens, Robert L; Kehlmann, Geoffrey B; Wellman, Andrew; Rahangdale, Shilpa; Yim-Yeh, Susie; White, David P; Malhotra, Atul