Keiser Megan S相关文献与解析，生知库 | 链接生命科学的每一步

APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

APOE2基因疗法可减少阿尔茨海默病小鼠模型中的淀粉样蛋白沉积，并改善神经炎症和神经退行性变标志物。

doi:10.1101/2023.08.14.552850

Jackson, Rosemary J; Keiser, Megan S; Meltzer, Jonah C; Fykstra, Dustin P; Dierksmeier, Steven E; Melloni, Alexandra; Nakajima, Tsuneo; Tecedor, Luis; Ranum, Paul T; Carrell, Ellie; Chen, YongHong; Holtzman, David M; Davidson, Beverly L; Hyman, Bradley T

RNA Interference of Human Î±-Synuclein in Mouse.

RNA干扰人α-突触核蛋白在小鼠体内的表达

期刊:Frontiers in Neurology

影响因子:2.8

doi:10.3389/fneur.2017.00013

Kim Young-Cho, Miller Adam, Lins Livia C R F, Han Sang-Woo, Keiser Megan S, Boudreau Ryan L, Davidson Beverly L, Narayanan Nandakumar S

RNAi prevents and reverses phenotypes induced by mutant human ataxin-1

RNAi可预防和逆转突变型人类共济蛋白-1诱导的表型

期刊:Annals of Neurology

影响因子:7.7

doi:10.1002/ana.24789

Keiser, Megan S; Monteys, Alejandro Mas; Corbau, Romuald; Gonzalez-Alegre, Pedro; Davidson, Beverly L

发表日期：2016

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Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia

基因抑制策略在显性遗传神经退行性疾病中的应用：以亨廷顿病和脊髓小脑性共济失调为例

期刊:Human Molecular Genetics

影响因子:3.2

doi:10.1093/hmg/ddv442

Keiser, Megan S; Kordasiewicz, Holly B; McBride, Jodi L

神经科学

发表日期：2016

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Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy

广泛应用共济失调蛋白1基因沉默技术治疗1型脊髓小脑性共济失调症（Rhesaxin 1 ataxin atalytic ata）

期刊:Brain

影响因子:11.7

doi:10.1093/brain/awv292

Keiser, Megan S; Kordower, Jeffrey H; Gonzalez-Alegre, Pedro; Davidson, Beverly L

Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapy.

将 RNAi 表达载体递送至小脑深部核团后可获得广泛的治疗益处：对 1 型脊髓小脑性共济失调治疗的意义

期刊:Molecular Therapy

影响因子:12

doi:10.1038/mt.2013.279

Keiser Megan S, Boudreau Ryan L, Davidson Beverly L

其它

发表日期：2014

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Recent advances in RNA interference therapeutics for CNS diseases

RNA干扰疗法在治疗中枢神经系统疾病方面的最新进展

期刊:Neurotherapeutics

影响因子:6.9

doi:10.1007/s13311-013-0183-8

Ramachandran, Pavitra S; Keiser, Megan S; Davidson, Beverly L

神经科学

发表日期：2013

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RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1

RNAi 或过表达：脊髓小脑性共济失调 1 型的替代疗法

期刊:Neurobiology of Disease

影响因子:5.6

doi:10.1016/j.nbd.2013.04.003

Keiser, Megan S; Geoghegan, James C; Boudreau, Ryan L; Lennox, Kim A; Davidson, Beverly L

神经科学

发表日期：2013

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Current trends in gene therapy to treat inherited disorders of the brain

目前基因疗法治疗遗传性脑部疾病的发展趋势

Cochlear transduction via cerebrospinal fluid delivery of AAV in non-human primates

在非人灵长类动物中通过脑脊液递送腺相关病毒（AAV）进行耳蜗转导

APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

APOE2基因疗法可减少阿尔茨海默病小鼠模型中的淀粉样蛋白沉积，并改善神经炎症和神经退行性变标志物。

RNA Interference of Human Î±-Synuclein in Mouse.

RNA干扰人α-突触核蛋白在小鼠体内的表达

RNAi prevents and reverses phenotypes induced by mutant human ataxin-1

RNAi可预防和逆转突变型人类共济蛋白-1诱导的表型

Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia

基因抑制策略在显性遗传神经退行性疾病中的应用：以亨廷顿病和脊髓小脑性共济失调为例

Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy

广泛应用共济失调蛋白1基因沉默技术治疗1型脊髓小脑性共济失调症（Rhesaxin 1 ataxin atalytic ata）

Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapy.

将 RNAi 表达载体递送至小脑深部核团后可获得广泛的治疗益处：对 1 型脊髓小脑性共济失调治疗的意义

Recent advances in RNA interference therapeutics for CNS diseases

RNA干扰疗法在治疗中枢神经系统疾病方面的最新进展

RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1

RNAi 或过表达：脊髓小脑性共济失调 1 型的替代疗法