日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant

GABA能神经元谱系发育决定了弥漫性半球胶质瘤(H3G34突变型)中具有临床意义的靶点

Ilon Liu ,Gustavo Alencastro Veiga Cruzeiro ,Lynn Bjerke ,Rebecca F Rogers ,Yura Grabovska ,Alexander Beck ,Alan Mackay ,Tara Barron ,Olivia A Hack ,Michael A Quezada ,Valeria Molinari ,McKenzie L Shaw ,Marta Perez-Somarriba ,Sara Temelso ,Florence Raynaud ,Ruth Ruddle ,Eshini Panditharatna ,Bernhard Englinger ,Hafsa M Mire ,Li Jiang ,Andrezza Nascimento ,Jenna LaBelle ,Rebecca Haase ,Jacob Rozowsky ,Sina Neyazi ,Alicia-Christina Baumgartner ,Sophia Castellani ,Samantha E Hoffman ,Amy Cameron ,Murry Morrow ,Quang-De Nguyen ,Giulia Pericoli ,Sibylle Madlener ,Lisa Mayr ,Christian Dorfer ,Rene Geyeregger ,Christopher Rota ,Gerda Ricken ,Keith L Ligon ,Sanda Alexandrescu ,Rodrigo T Cartaxo ,Benison Lau ,Santhosh Uphadhyaya ,Carl Koschmann ,Emelie Braun ,Miri Danan-Gotthold ,Lijuan Hu ,Kimberly Siletti ,Erik Sundström ,Rebecca Hodge ,Ed Lein ,Sameer Agnihotri ,David D Eisenstat ,Simon Stapleton ,Andrew King ,Cristina Bleil ,Angela Mastronuzzi ,Kristina A Cole ,Angela J Waanders ,Angel Montero Carcaboso ,Ulrich Schüller ,Darren Hargrave ,Maria Vinci ,Fernando Carceller ,Christine Haberler ,Irene Slavc ,Sten Linnarsson ,Johannes Gojo ,Michelle Monje ,Chris Jones ,Mariella G Filbin

Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression

Velcrin 分子胶可诱导 PDE3A 和 SLFN12 表达较高的胶质母细胞瘤细胞凋亡

Elisa Aquilanti, Silvia Goldoni, Andrew Baker, Kristyna Kotynkova, Sawyer Andersen, Vincent Bozinov, Galen F Gao, Andrew D Cherniack, Martin Lange, Ralf Lesche, Charlotte Kopitz, Philip Lienau, Timothy A Lewis, Marine Garrido, Stefan Gradl, Henrik Seidel, Yuen-Yi Tseng, Keith L Ligon, Patrick Y Wen,

A heterogeneous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase

针对单一致癌激酶诱导的异质性药物转录组学景观

Ross M Giglio, Nicholas Hou, Adeya Wyatt, Justin Hong, Lingting Shi, Mathini Vaikunthan, Henry Fuchs, Jose Pomarino Nima, Seth W Malinowski, Keith L Ligon, José R McFaline-Figueroa, Nir Yosef, Elham Azizi, José L McFaline-Figueroa1

Measuring single-cell density with high throughput enables dynamic profiling of immune cell and drug response from patient samples

高通量测量单细胞密度可以动态分析患者样本的免疫细胞和药物反应

Weida Wu, Sarah H Ishamuddin, Thomas W Quinn, Smitha Yerrum, Ye Zhang, Lydie L Debaize, Pei-Lun Kao, Sarah Marie Duquette, Mark A Murakami, Morvarid Mohseni, Kin-Hoe Chow, Teemu P Miettinen, Keith L Ligon, Scott R Manalis

Pilot trial of perampanel on peritumoral hyperexcitability and clinical outcomes in newly diagnosed high-grade glioma

吡仑帕奈对新诊断高级别胶质瘤肿瘤周围兴奋性及临床结果的初步试验

Steven Tobochnik, Michael S Regan, Maria K C Dorotan, Dustine Reich, Emily Lapinskas, Md Amin Hossain, Sylwia Stopka, Sandro Santagata, Melissa M Murphy, Omar Arnaout, Wenya Linda Bi, E Antonio Chiocca, Alexandra J Golby, Michael A Mooney, Timothy R Smith, Keith L Ligon, Patrick Y Wen, Nathalie Y R

(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers

(R)-2-羟基戊二酸抑制 KDM5 组蛋白赖氨酸去甲基化酶,从而促进 IDH 突变癌症的转化

Kathryn Gunn, Matti Myllykoski, John Z Cao, Manna Ahmed, Bofu Huang, Betty Rouaisnel, Bill H Diplas, Michael M Levitt, Ryan Looper, John G Doench, Keith L Ligon, Harley I Kornblum, Samuel K McBrayer, Hai Yan, Cihangir Duy, Lucy A Godley, Peppi Koivunen, Julie-Aurore Losman

High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers

同一组织切片的高重免疫荧光成像和传统组织学用于发现基于图像的生物标志物

Jia-Ren Lin #, Yu-An Chen #, Daniel Campton #, Jeremy Cooper, Shannon Coy, Clarence Yapp, Juliann B Tefft, Erin McCarty, Keith L Ligon, Scott J Rodig, Steven Reese, Tad George, Sandro Santagata, Peter K Sorger

Telomerase inhibition is an effective therapeutic strategy in TERT promoter-mutant glioblastoma models with low tumor volume

端粒酶抑制是肿瘤体积较小的TERT启动子突变型胶质母细胞瘤模型的一种有效治疗策略。

Elisa Aquilanti ,Lauren Kageler ,Jacqueline Watson ,Duncan M Baird ,Rhiannon E Jones ,Marie Hodges ,Zsofia M Szegletes ,John G Doench ,Craig A Strathdee ,Jose Ricardo Mc Faline Figueroa ,Keith L Ligon ,Matthew Beck ,Patrick Y Wen ,Matthew Meyerson

Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma

动态BH3谱分析可识别用于治疗恶性胸膜间皮瘤的促凋亡药物组合

Danielle S Potter ,Ruochen Du ,Stephan R Bohl ,Kin-Hoe Chow ,Keith L Ligon ,Raphael Bueno ,Anthony Letai

Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma

单细胞分析和斑马鱼模型揭示 LGALS1 是胶质母细胞瘤的免疫调节靶点

Lise Finotto, Basiel Cole, Wolfgang Giese, Elisabeth Baumann, Annelies Claeys, Maxime Vanmechelen, Brecht Decraene, Marleen Derweduwe, Nikolina Dubroja Lakic, Gautam Shankar, Madhu Nagathihalli Kantharaju, Jan Philipp Albrecht, Ilse Geudens, Fabio Stanchi, Keith L Ligon, Bram Boeckx, Diether Lambrec