日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging

非坏死性凋亡的MLKL功能会损伤线粒体并促进造血干细胞衰老。

Yamada, Yuta; Yang, Jinjing; Saiki-Tsuchiya, Akiho; Watanabe, Yuji; Koide, Shuhei; Murai, Shin; Sorimachi, Yuriko; Fukuda, Yu; Sumiyama, Kenta; Sagara, Hiroshi; Nakano, Hiroyasu; Takubo, Keiyo; Iwama, Atsushi; Yamashita, Masayuki

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting.

CXCR4 可诱导 CAR-T 细胞在耗竭后形成记忆,从而实现持久的白血病靶向治疗。

Itoh-Nakadai Ari, Liang Minggao, Shindo Michiho, Bibi Chen, Tomizawa-Murasawa Mariko, Fujiki Saera, Kaneko Akiko, Kanamaru Emi, Hashimoto Mari, Kajita Hiroshi, Ando Yoshinari, Kojima Miki, Moody Jonathan, Iwasaki Makoto, Takagi Shinsuke, Nakagawa Ryo, Agrawal Saumya, Amitani-Iijima Hanae, Sato Kaori, Sorimachi Yuriko, Suzuki Nahoko, Fukami Takehiro, Hanada Kazuharu, Morita Satoshi, Katsura Kazushige, Matsumoto Takehisa, Kobayashi Maiko, Kato Masahiko, Negishi Yasuyuki, Shirouzu Mikako, Najima Yuho, Takubo Keiyo, Hon Chung Chau, Uchida Naoyuki, Taniguchi Shuichi, Momozawa Yukihide, Carninci Piero, Shultz Leonard D, Saito Yoriko, de Hoon Michiel, Shin Jay W, Ishikawa Fumihiko

Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions.

消除异常的糖酵解相互作用可以消除衰老细胞,缓解与衰老相关的机能障碍。

Mikawa Takumi, Kameda Masahiro, Ikari Sumiko, Shibata Eri, Liu Shuyu, Miyagawa Sawa, Ono Koh, Ito Tomiko, Yoshizawa Akihiko, Sugimoto Masataka, Shibuya Shuichi, Shimizu Takahiko, Almunia Julio, Ogiso Noboru, Revêchon Gwladys, Palazzo Alberta, Bernard David, Kanda Hiroaki, Soga Tomoyoshi, Takubo Keiyo, Morioka Shin, Sasaki Junko, Sasaki Takehiko, Itamoto Akihiro, Fujii Takayuki, Seno Hiroshi, Inagaki Nobuya, Kondoh Hiroshi

Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing

骨髓中非神经源性乙酰胆碱减少会引发与年龄相关的干细胞/祖细胞归巢缺陷

Takayuki Morikawa ,Shinya Fujita ,Yuki Sugiura ,Shinpei Tamaki ,Miho Haraguchi ,Kohei Shiroshita ,Shintaro Watanuki ,Hiroshi Kobayashi ,Hikari Kanai-Sudo ,Yoshiko Naito ,Noriyo Hayakawa ,Tomomi Matsuura ,Takako Hishiki ,Minoru Matsui ,Masato Tsutsui ,Makoto Suematsu ,Keiyo Takubo

JMJD3-mediated senescence is required to overcome stress-induced hematopoietic defects

JMJD3介导的衰老是克服应激诱导的造血缺陷所必需的。

Yuichiro Nakata ,Takeshi Ueda ,Yasuyuki Sera ,Miho Koizumi ,Katsutoshi Imamura ,Akinori Kanai ,Ken-Ichiro Ikeda ,Norimasa Yamasaki ,Akiko Nagamachi ,Kohei Kobatake ,Masataka Taguchi ,Yusuke Sotomaru ,Tatsuo Ichinohe ,Zen-Ichiro Honda ,Takuro Nakamura ,Ichiro Manabe ,Toshio Suda ,Keiyo Takubo ,Osamu Kaminuma ,Hiroaki Honda

Author Correction: JMJD3-mediated senescence is required to overcome stress-induced hematopoietic defects

作者更正:JMJD3介导的衰老是克服应激诱导的造血缺陷所必需的。

Nakata, Yuichiro; Ueda, Takeshi; Sera, Yasuyuki; Koizumi, Miho; Imamura, Katsutoshi; Kanai, Akinori; Ikeda, Ken-Ichiro; Yamasaki, Norimasa; Nagamachi, Akiko; Kobatake, Kohei; Taguchi, Masataka; Sotomaru, Yusuke; Ichinohe, Tatsuo; Honda, Zen-Ichiro; Nakamura, Takuro; Manabe, Ichiro; Suda, Toshio; Takubo, Keiyo; Kaminuma, Osamu; Honda, Hiroaki

Author Correction: RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

作者更正:RNaseH2A下调通过衰老细胞和癌细胞中的基因组DNA片段化驱动炎症基因表达。

Sugawara, Sho; Okada, Ryo; Loo, Tze Mun; Tanaka, Hisamichi; Miyata, Kenichi; Chiba, Masatomo; Kawasaki, Hiroko; Katoh, Kaoru; Kaji, Shizuo; Maezawa, Yoshiro; Yokote, Koutaro; Nakayama, Mizuho; Oshima, Masanobu; Nagao, Koji; Obuse, Chikashi; Nagayama, Satoshi; Takubo, Keiyo; Nakanishi, Akira; Kanemaki, Masato T; Hara, Eiji; Takahashi, Akiko

Biallelic TEDC1 variants cause a new syndrome with severe growth impairment and endocrine complications

双等位基因TEDC1变异会导致一种新的综合征,其特征是严重的生长发育障碍和内分泌并发症。

Miyake, Noriko; Shiga, Kentaro; Hasegawa, Yuya; Iwabuchi, Chisato; Shiroshita, Kohei; Kobayashi, Hiroshi; Takubo, Keiyo; Velilla, Fabien; Maeno, Akiteru; Kawasaki, Toshihiro; Imai, Yukiko; Sakai, Noriyoshi; Hirose, Tomonori; Fujita, Atsushi; Takahashi, Hidehisa; Okamoto, Nobuhiko; Enokizono, Mikako; Iwasaki, Shiho; Ito, Shuichi; Matsumoto, Naomichi

LCN2-mediated ferroptosis resistance in tissue homeostasis and early-stage tumorigenesis of the fallopian tube epithelium.

LCN2介导的铁死亡抵抗在输卵管上皮组织稳态和早期肿瘤发生中的作用

Imaeda Keiyo, Tamura Tomohiro, Nagai Shimpei, Sugihara Eiji, Yamasaki Juntaro, Otsuki Yuji, Nakamura Kohei, Takeda Takashi, Nakamura Kanako, Nogami Yuya, Tsuji Kosuke, Chiyoda Tatsuyuki, Kisu Iori, Kobayashi Yusuke, Banno Kouji, Yamaguchi Rui, Sakurada Kazuhiro, Saya Hideyuki, Aoki Daisuke, Ahmed Ahmed Ashour, Nagano Osamu, Masuda Kenta, Yamagami Wataru

Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis

造血干细胞中PFKFB3的上下文依赖性修饰促进无氧糖酵解,并确保应激性造血。

Shintaro Watanuki # ,Hiroshi Kobayashi # ,Yuki Sugiura ,Masamichi Yamamoto ,Daiki Karigane ,Kohei Shiroshita ,Yuriko Sorimachi ,Shinya Fujita ,Takayuki Morikawa ,Shuhei Koide ,Motohiko Oshima ,Akira Nishiyama ,Koichi Murakami ,Miho Haraguchi ,Shinpei Tamaki ,Takehiro Yamamoto ,Tomohiro Yabushita ,Yosuke Tanaka ,Go Nagamatsu ,Hiroaki Honda ,Shinichiro Okamoto ,Nobuhito Goda ,Tomohiko Tamura ,Ayako Nakamura-Ishizu ,Makoto Suematsu ,Atsushi Iwama ,Toshio Suda ,Keiyo Takubo