日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer

LKB1和KEAP1的同时缺失增强了KRAS突变型肺癌中SHMT介导的抗氧化防御。

Hyun Min Lee ,Nefertiti Muhammad ,Elizabeth L Lieu ,Feng Cai ,Jiawei Mu ,Yun-Sok Ha ,Guoshen Cao ,Chamey Suchors ,Kenneth Joves ,Constantinos Chronis ,Kailong Li ,Gregory S Ducker ,Kellen Olszewski ,Ling Cai ,Derek B Allison ,Sara E Bachert ,William R Ewing ,Harvey Wong ,Hyosun Seo ,Isaac Y Kim ,Brandon Faubert ,James Kim ,Jiyeon Kim

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

细胞周期阻滞诱导脂滴形成并赋予细胞铁死亡抵抗力。

Hyemin Lee,Amber Horbath,Lavanya Kondiparthi,Jitendra Kumar Meena,Guang Lei,Shayani Dasgupta,Xiaoguang Liu,Li Zhuang,Pranavi Koppula,Mi Li,Iqbal Mahmud,Bo Wei,Philip L Lorenzi,Khandan Keyomarsi,Masha V Poyurovsky,Kellen Olszewski,Boyi Gan

Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis

铁死亡途径的蛋白质组学分析揭示了 CEPT1 在抑制铁死亡中的作用

Xiaoguang Liu, Zhen Chen, Yuelong Yan, Fereshteh Zandkarimi, Litong Nie, Qidong Li, Amber Horbath, Kellen Olszewski, Lavanya Kondiparthi, Chao Mao, Hyemin Lee, Li Zhuang, Masha Poyurovsky, Brent R Stockwell, Junjie Chen, Boyi Gan

One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade

补充一碳单位可促进肿瘤浸润T细胞中的嘌呤合成,并增强免疫检查点阻断作用。

Xincheng Xu ,Zihong Chen ,Caroline R Bartman ,Xi Xing ,Kellen Olszewski ,Joshua D Rabinowitz

Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition

回复:DHODH 抑制剂通过抑制 FSP1 来增加对铁死亡的敏感性

Chao Mao, Xiaoguang Liu, Yuelong Yan, Kellen Olszewski, Boyi Gan

Spatial mapping of mitochondrial networks and bioenergetics in lung cancer

肺癌线粒体网络和生物能量学的空间映射

Mingqi Han, Eric A Bushong, Mayuko Segawa, Alexandre Tiard, Alex Wong, Morgan R Brady, Milica Momcilovic, Dane M Wolf, Ralph Zhang, Anton Petcherski, Matthew Madany, Shili Xu, Jason T Lee, Masha V Poyurovsky, Kellen Olszewski, Travis Holloway, Adrian Gomez, Maie St John, Steven M Dubinett, Carla M K

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

肌动蛋白细胞骨架对二硫键应激的脆弱性介导二硫键凋亡

Xiaoguang Liu #, Litong Nie #, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan

SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells

SLC7A11 表达水平决定癌细胞对氧化应激的不同反应

Yuelong Yan, Hongqi Teng, Qinglei Hang, Lavanya Kondiparthi, Guang Lei, Amber Horbath, Xiaoguang Liu, Chao Mao, Shiqi Wu, Li Zhuang, M James You, Masha V Poyurovsky, Li Ma, Kellen Olszewski, Boyi Gan

One-carbon unit supplementation fuels tumor-infiltrating T cells and augments checkpoint blockade

单碳单位补充为肿瘤浸润 T 细胞提供能量并增强检查点阻断

Xincheng Xu, Zihong Chen, Caroline R Bartman, Xi Xing, Kellen Olszewski, Joshua D Rabinowitz

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

可靶向的 CoQ-FSP1 轴驱动 KEAP1 非活性肺癌的铁死亡和放射抗性

Pranavi Koppula #, Guang Lei #, Yilei Zhang, Yuelong Yan, Chao Mao, Lavanya Kondiparthi, Jiejun Shi, Xiaoguang Liu, Amber Horbath, Molina Das, Wei Li, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan