日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A phase I study targeting the APE1/Ref-1 redox signaling protein with APX3330: first clinical agent targeting APE1/Ref-1 in cancer

APX3330 靶向 APE1/Ref-1 氧化还原信号蛋白的 I 期研究:首个靶向 APE1/Ref-1 的癌症临床药物

Kelley, Mark R; Wan, Jun; Liu, Sheng; Kpenu, Eyram; Wireman, Randall; Mosley, Amber L; Liu, Hao; Lakhani, Nehal J; Shahda, Safi; O'Neil, Bert; Opyrchal, Mateusz; Messmann, Richard A

Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells

Ref-1 氧化还原活性调节内皮细胞中的经典 Wnt 信号通路

Hartman, Gabriella D; Sishtla, Kamakshi; Kpenu, Eyram K; Mijit, Mahmut; Muniyandi, Anbukkarasi; Jo, Ha-Neul; Junge, Harald J; Shaw, Aaron; Bischof, Daniela; Liu, Sheng; Wan, Jun; Kelley, Mark R; Corson, Timothy W

The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling.

人类胰腺导管腺癌 (PDAC) 中过氧化物酶-1 的缺失,与 Ref-1 氧化还原信号的抑制相结合,会显著降低细胞存活率和肿瘤生长。

Kiran Sonia, Wireman Randall S, Peil Jacqueline, Mitchell Dana K, Potchanant Elizabeth Sierra, Rai Ratan, Vilseck Jonah Z, Cao Sha, Haiaty Sanya, Georgiadis Millie M, Fishel Melissa L, Kelley Mark R

Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease 1

化学诱导的多功能脱嘌呤/脱嘧啶核酸内切酶1的部分展开

Rai, Ratan; Dawodu, Olabode I; Meng, Jingwei; Johnson, Steven M; Vilseck, Jonah Z; Kelley, Mark R; Ziarek, Joshua J; Georgiadis, Millie M

A Phase I study targeting the APE1/Ref-1 redox signaling protein with APX3330: First clinical agent targeting APE1/Ref-1 in Cancer

一项针对 APE1/Ref-1 氧化还原信号蛋白的 I 期研究,使用 APX3330:首个针对癌症中 APE1/Ref-1 的临床药物

Kelley, Mark R; Wan, Jun; Liu, Sheng; Kpenu, Eyram; Wireman, Randall; Mosley, Amber L; Liu, Hao; Lakhani, Nehal J; Shahda, Safi; O'Neil, Bert; Opyrchal, Mateusz; Messmann, Richard A

Targeting APE1 endonuclease activity impairs metastasis and enhances genotoxic therapy response in pancreatic cancer

靶向APE1核酸内切酶活性可抑制胰腺癌转移并增强基因毒性疗法的疗效

Kpenu, Eyram K; Mijiti, Mahmut; Gampala, Silpa; Wan, Jun; Liu, Sheng; Wireman, Randall S; Peil, Jacqueline; Mitchell, Dana K; Haiaty, Sanya; Sardar, Rajesh; Sharma, Akanksha; Georgiadis, Millie M; Fishel, Melissa L; Kelley, Mark R

Bridging population pharmacokinetic and semimechanistic absorption modeling of APX3330

APX3330 的群体药代动力学和半机制吸收模型的桥接

Silva, Larissa L; Stratford, Robert E; Messmann, Richard; Kelley, Mark R; Quinney, Sara K

Combating PDAC Drug Resistance: The Role of Ref-1 Inhibitors in Accelerating Progress in Pancreatic Cancer Research

对抗胰腺癌耐药性:Ref-1抑制剂在加速胰腺癌研究进展中的作用

Kpenu, Eyram K; Kelley, Mark R

Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells

鉴定人视网膜内皮细胞中受 APE1/Ref-1 调控的新通路

Mijit, Mahmut; Liu, Sheng; Sishtla, Kamakshi; Hartman, Gabriella D; Wan, Jun; Corson, Timothy W; Kelley, Mark R

APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease

APE1/Ref-1 作为炎症性肠病的治疗靶点

Sahakian, Lauren; Robinson, Ainsley M; Sahakian, Linda; Stavely, Rhian; Kelley, Mark R; Nurgali, Kulmira