日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De Novo Design of Proteins That Bind Naphthalenediimides, Powerful Photooxidants with Tunable Photophysical Properties

从头设计能结合萘二酰亚胺(一种具有可调光物理性质的强效光氧化剂)的蛋白质

Mann, Samuel I; Lin, Zhi; Tan, Sophia K; Zhu, Jiaqi; Widel, Zachary X W; Bakanas, Ian; Mansergh, Jarrett P; Liu, Rui; Kelly, Mark J S; Wu, Yibing; Wells, James A; Therien, Michael J; DeGrado, William F

AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid

AcrIF11 是一种强效的 CRISPR 特异性 ADP-核糖基转移酶,由噬菌体和质粒编码。

Chen, Daphne F; Roe, Leah T; Yuping, Li; Borges, Adair L; Zhang, Jenny Y; Babbar, Palak; Maji, Sourobh; Stevens, Maisie G V; Correy, Galen J; Diolaiti, Morgan E; Smith, Dominique H; Ashworth, Alan; Stroud, Robert M; Kelly, Mark J S; Bondy-Denomy, Joseph; Fraser, James S

Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening

通过高通量筛选鉴定KDM5A的PHD1指状结构域的配体

Ortiz, Gloria; Longbotham, James E; Qin, Sophia L; Zhang, Meng Yao; Lee, Gregory M; Neitz, R Jeffrey; Kelly, Mark J S; Arkin, Michelle R; Fujimori, Danica Galonić

Deep learning guided design of dynamic proteins

基于深度学习的动态蛋白质设计

Guo, Amy B; Akpinaroglu, Deniz; Kelly, Mark J S; Kortemme, Tanja

Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A

组蛋白去甲基化酶KDM5A的PHD1结构域对组蛋白H3甲基化状态的识别

Longbotham, James E; Kelly, Mark J S; Fujimori, Danica Galonić

Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy

利用氟核磁共振波谱法探测KRas开关II槽

Peacock, D Matthew; Kelly, Mark J S; Shokat, Kevan M

Expanding the space of protein geometries by computational design of de novo fold families

通过计算设计从头折叠家族来扩展蛋白质几何空间

Pan, Xingjie; Thompson, Michael C; Zhang, Yang; Liu, Lin; Fraser, James S; Kelly, Mark J S; Kortemme, Tanja

Computational design of a modular protein sense-response system

模块化蛋白质感知-响应系统的计算设计

Glasgow, Anum A; Huang, Yao-Ming; Mandell, Daniel J; Thompson, Michael; Ritterson, Ryan; Loshbaugh, Amanda L; Pellegrino, Jenna; Krivacic, Cody; Pache, Roland A; Barlow, Kyle A; Ollikainen, Noah; Jeon, Deborah; Kelly, Mark J S; Fraser, James S; Kortemme, Tanja

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain.

可穿透细胞的蝎毒素能够对 TRPA1 和疼痛进行模式特异性调节

Lin King John V, Emrick Joshua J, Kelly Mark J S, Herzig Volker, King Glenn F, Medzihradszky Katalin F, Julius David

The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles.

中心体蛋白 CM2 结构域是一个多功能结合结构域,具有独特的细胞周期作用

Citron Y Rose, Fagerstrom Carey J, Keszthelyi Bettina, Huang Bo, Rusan Nasser M, Kelly Mark J S, Agard David A