日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Correction to "Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties"

对“具有改进药理特性的强效、选择性吡咯并嘧啶PDE11A4抑制剂”的更正

Mahmood, Shams Ul; Boddu, Rama Krishna; Eberhard, Jeremy; Hoffman, Charles S; Gordon, John; Colussi, Dennis; Childers, Wayne; Amurrio, Elvis; Danaher, Marie; Kelly, Michy P; Rotella, David P

Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties

具有改进药理特性的高效、选择性吡咯并嘧啶类PDE11A4抑制剂

Mahmood, Shams Ul; Boddu, Rama Krishna; Eberhard, Jeremy; Hoffman, Charles S; Gordon, John; Colussi, Dennis; Childers, Wayne; Amurrio, Elvis; Danaher, Marie; Kelly, Michy P; Rotella, David P

Age-Related Upregulation and Strong Expression Correlation of the Proinflammatory Cytokines IL-1β and IL-6 Across Multiple Segments of the Mouse Eye

小鼠眼部多个节段中促炎细胞因子IL-1β和IL-6的表达随年龄增长而上调,且二者表达呈强相关性。

Greene, Haley; Sbornova, Irina; Kelly, Michy P

Cyclic nucleotide phosphodiesterases as drug targets

环核苷酸磷酸二酯酶作为药物靶点

Kelly, Michy P; Nikolaev, Viacheslav O; Gobejishvili, Leila; Lugnier, Claire; Hesslinger, Christian; Nickolaus, Peter; Kass, David A; Pereira de Vasconcelos, Walma; Fischmeister, Rodolphe; Brocke, Stefan; Epstein, Paul M; Piazza, Gary A; Keeton, Adam B; Zhou, Gang; Abdel-Halim, Mohammad; Abadi, Ashraf H; Baillie, George S; Giembycz, Mark A; Bolger, Graeme; Snyder, Gretchen; Tasken, Kjetil; Saidu, Nathaniel E B; Schmidt, Martina; Zaccolo, Manuela; Schermuly, Ralph T; Ke, Hengming; Cote, Rick H; Mohammadi Jouabadi, Soroush; Roks, Anton J M

Age-Related Increases in PDE11A4 Protein Expression Trigger Liquid-Liquid Phase Separation (LLPS) of the Enzyme That Can Be Reversed by PDE11A4 Small Molecule Inhibitors.

与年龄相关的 PDE11A4 蛋白表达增加会引发该酶的液-液相分离 (LLPS),而 PDE11A4 小分子抑制剂可以逆转这一现象

Amurrio Elvis, Patel Janvi H, Danaher Marie, Goodwin Madison, Kargbo Porschderek, Klimentova Eliska, Lin Sonia, Kelly Michy P

First Demonstration of In Vivo PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders

首次证实体内PDE11A4靶点结合可用于治疗与年龄相关的记忆障碍

Mahmood, Shams Ul; Eberhard, Jeremy; Hoffman, Charles S; Colussi, Dennis; Gordon, John; Childers, Wayne; Amurrio, Elvis; Patel, Janvi; Kelly, Michy P; Rotella, David P

First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline

首次优化新型、高效、选择性PDE11A4抑制剂以治疗与年龄相关的认知衰退

Mahmood, Shams Ul; Lozano Gonzalez, Mariana; Tummalapalli, Sreedhar; Eberhard, Jeremy; Ly, Judy; Hoffman, Charles S; Kelly, Michy P; Gordon, John; Colussi, Dennis; Childers, Wayne; Rotella, David P

Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories

海马体中PDE11A4的保守性年龄相关性增加会导致意想不到的蛋白病变和社交联想记忆的认知衰退。

Pilarzyk, Katy; Porcher, Latarsha; Capell, William R; Burbano, Steven D; Davis, Jeff; Fisher, Janet L; Gorny, Nicole; Petrolle, Siena; Kelly, Michy P

A genetic basis for friendship? Homophily for membrane-associated PDE11A-cAMP-CREB signaling in CA1 of hippocampus dictates mutual social preference in male and female mice

友谊的遗传基础?海马CA1区膜相关PDE11A-cAMP-CREB信号通路的同源性决定了雄性和雌性小鼠的相互社交偏好。

Smith, Abigail J; Farmer, Reagan; Pilarzyk, Katy; Porcher, Latarsha; Kelly, Michy P

Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease

磷酸二酯酶PDE2A和PDE10A均会随着年龄增长而改变人脑中的mRNA表达,但只有PDE2A的改变会因精神疾病而呈现区域特异性。

Farmer, Reagan; Burbano, Steven D; Patel, Neema S; Sarmiento, Angelo; Smith, Abigail J; Kelly, Michy P