A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards NK-like phenotype impairs T cell function and persistence
一项针对接受异基因造血干细胞移植后仍处于活动期的急性髓系白血病患者的WT1特异性TCR基因治疗I/II期试验:NK样表型偏向会损害T细胞功能和持久性。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-60394-0
Mazziotta, Francesco; Martin, Lauren E; Egan, Daniel N; Bar, Merav; Kinsella, Sinéad; Paulson, Kelly G; Voillet, Valentin; Lahman, Miranda C; Hunter, Daniel; Schmitt, Thomas M; Duerkopp, Natalie; Yeung, Cecilia C S; Tang, Tzu-Hao; Gottardo, Raphael; Asano, Yuta; Wilcox, Elise C; Lee, Bo; Zhang, Tianzi; Lopedote, Paolo; Penter, Livius; Wu, Catherine J; Milano, Filippo; Greenberg, Philip D; Chapuis, Aude G
T细胞
细胞生物学
基因治疗
白血病
T细胞
WT1
干细胞
发育与干细胞
免疫/内分泌