日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers

小分子抑制驱动蛋白KIF18A揭示了染色体不稳定癌症中富集的有丝分裂脆弱性

Marc Payton ,Brian Belmontes ,Kelly Hanestad ,Jodi Moriguchi ,Kui Chen ,John D McCarter ,Grace Chung ,Maria Stefania Ninniri ,Jan Sun ,Raffi Manoukian ,Stuart Chambers ,Seok-Man Ho ,Robert J M Kurzeja ,Katheryne Z Edson ,Upendra P Dahal ,Tian Wu ,Sharon Wannberg ,Pedro J Beltran ,Jude Canon ,Andrew S Boghossian ,Matthew G Rees ,Melissa M Ronan ,Jennifer A Roth ,Sheroy Minocherhomji ,Matthew P Bourbeau ,Jennifer R Allen ,Angela Coxon ,Nuria A Tamayo ,Paul E Hughes

Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes

Aurora 激酶与 AMG 900 的双重靶向作用表现出针对急性髓系白血病的强效临床前活性,且具有独特的有丝分裂后结果

Marc Payton, Hung-Kam Cheung, Maria Stefania S Ninniri, Christian Marinaccio, William C Wayne, Kelly Hanestad, John D Crispino, Gloria Juan, Angela Coxon