日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-based design of an opioid receptor modulator for enhanced morphine analgesia

基于结构的阿片受体调节剂设计及其在增强吗啡镇痛中的应用

Wang, Yue; Luo, Ping; Xu, Haiyan; Zhan, Li; Sakamoto, Kensuke; Li, Mingyu; Wang, Jing; Huang, Xi-Ping; Zhou, Jianhui; Liu, Tao; Suo, Yanrui; Fan, Wenjia; He, Xinheng; Xu, Youwei; Cai, Yongjie; Wang, Chao; Zhao, Yuxi; Dai, Antao; Lai, Yali; Yuan, Qingning; Hu, Wen; Wu, Kai; Yang, Dehua; Cheng, Xi; Lu, Xiaojie; Krumm, Brian; Kenakin, Terry; Zhang, Jian; Roth, Bryan L; Gao, Zhaobing; Xu, H Eric; Zhuang, Youwen

Molecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes.

通过α-阿片受体-G蛋白复合物的反向激动作用的分子机制

Tyson Aaliyah S, Khan Saif, Motiwala Zenia, Han Gye Won, Zhang Zixin, Ranjbar Mohsen, Styrpejko Daniel, Ramos-Gonzalez Nokomis, Woo Stone, Villers Kelly, Landaker Delainey, Kenakin Terry, Shenvi Ryan, Majumdar Susruta, Gati Cornelius

Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Michael Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L

Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma M; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L

Community guidelines for GPCR ligand bias: IUPHAR review 32

GPCR配体偏向性社区指南:IUPHAR审查32

Kolb, Peter; Kenakin, Terry; Alexander, Stephen P H; Bermudez, Marcel; Bohn, Laura M; Breinholt, Christian S; Bouvier, Michel; Hill, Stephen J; Kostenis, Evi; Martemyanov, Kirill A; Neubig, Rick R; Onaran, H Ongun; Rajagopal, Sudarshan; Roth, Bryan L; Selent, Jana; Shukla, Arun K; Sommer, Martha E; Gloriam, David E

Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior

3-(4-氯苯基)-1-(苯乙基)脲类似物作为大麻素1型受体变构调节剂的开发:RTICBM-189可穿透血脑屏障并减弱可卡因渴求行为的复发

Nguyen, Thuy; Gamage, Thomas F; Finlay, David B; Decker, Ann M; Langston, Tiffany L; Barrus, Daniel; Glass, Michelle; Li, Jun-Xu; Kenakin, Terry P; Zhang, Yanan

Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68)

基于 Ogerin 的 G 蛋白偶联受体 68 (GPR68) 正向变构调节剂的设计、合成和表征

Yu, Xufen; Huang, Xi-Ping; Kenakin, Terry P; Slocum, Samuel T; Chen, Xin; Martini, Michael L; Liu, Jing; Jin, Jian

Diarylureas Containing 5-Membered Heterocycles as CB(1) Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation

含五元杂环的二芳基脲类化合物作为CB(1)受体变构调节剂:设计、合成及药理学评价

Nguyen, Thuy; Gamage, Thomas F; Decker, Ann M; German, Nadezhda; Langston, Tiffany L; Farquhar, Charlotte E; Kenakin, Terry P; Wiley, Jenny L; Thomas, Brian F; Zhang, Yanan

Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine

纳呋拉芬作为一种可减少阿片类药物用量的佐剂,通过增强靶向μ阿片受体激动剂吗啡的镇痛作用,进行临床前试验

Kaski, Shane W; White, Allison N; Gross, Joshua D; Trexler, Kristen R; Wix, Kim; Harland, Aubrie A; Prisinzano, Thomas E; Aubé, Jeffrey; Kinsey, Steven G; Kenakin, Terry; Siderovski, David P; Setola, Vincent

Analytical Pharmacology: How Numbers Can Guide Drug Discovery

分析药理学:数字如何指导药物发现

Kenakin, Terry