日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Generation of T cell responses against broad KRAS hotspot neoantigens for cell therapy or TCR discovery

针对广泛的KRAS热点新抗原产生T细胞反应,用于细胞治疗或TCR发现

Brandon P Conn,Jared L Dietze,Christian J Yee,Margaret M Hallisey,Irais Ortiz-Caraveo,Marit M van Buuren,Richard B Gaynor,Kendra C Foley,Jaewon Choi,Vikram R Juneja

Systematic discovery and validation of T cell targets directed against oncogenic KRAS mutations

系统性地发现和验证针对致癌性KRAS突变的T细胞靶点

Jaewon Choi,Scott P Goulding,Brandon P Conn,Christopher D McGann,Jared L Dietze,Jessica Kohler,Divya Lenkala,Antoine Boudot,Daniel A Rothenberg,Paul J Turcott,John R Srouji,Kendra C Foley,Michael S Rooney,Marit M van Buuren,Richard B Gaynor,Jennifer G Abelin,Terri A Addona,Vikram R Juneja

Improving T Cell Receptor On-Target Specificity via Structure-Guided Design

通过结构引导设计提高 T 细胞受体的靶向特异性

Lance M Hellman, Kendra C Foley, Nishant K Singh, Jesus A Alonso, Timothy P Riley, Jason R Devlin, Cory M Ayres, Grant L J Keller, Yuting Zhang, Craig W Vander Kooi, Michael I Nishimura, Brian M Baker

T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability

肽-MHC 适应性显著增强,T 细胞受体交叉反应性增强

Timothy P Riley, Lance M Hellman, Marvin H Gee, Juan L Mendoza, Jesus A Alonso, Kendra C Foley, Michael I Nishimura, Craig W Vander Kooi, K Christopher Garcia, Brian M Baker

Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells

关键生物学参数调节亲和力,作为 T 细胞受体基因修饰 T 细胞功能的决定因素

Timothy T Spear, Yuan Wang, Kendra C Foley, David C Murray, Gina M Scurti, Patricia E Simms, Elizabeth Garrett-Mayer, Lance M Hellman, Brian M Baker, Michael I Nishimura

HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer

HCV T 细胞受体链修饰可增强 T 细胞的表达、配对和抗原识别,从而实现过继转移

Kendra C Foley, Timothy T Spear, David C Murray, Kaoru Nagato, Elizabeth Garrett-Mayer, Michael I Nishimura

TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors

TCR 基因修饰的 T 细胞可有效治疗已确诊的丙型肝炎相关肝细胞癌肿瘤

Timothy T Spear, Glenda G Callender, Jeffrey J Roszkowski, Kelly M Moxley, Patricia E Simms, Kendra C Foley, David C Murray, Gina M Scurti, Mingli Li, Justin T Thomas, Alexander Langerman, Elizabeth Garrett-Mayer, Yi Zhang, Michael I Nishimura