日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations

利用计算方法设计具有更高开发性的治疗性抗体:高效遍历结合物分布图和挽救逃逸突变

Frédéric A Dreyer ,Constantin Schneider ,Aleksandr Kovaltsuk ,Daniel Cutting ,Matthew J Byrne ,Daniel A Nissley ,Henry Kenlay ,Claire Marks ,David Errington ,Richard J Gildea ,David Damerell ,Pedro Tizei ,Wilawan Bunjobpol ,John F Darby ,Ieva Drulyte ,Daniel L Hurdiss ,Sachin Surade ,Newton Wahome ,Douglas E V Pires ,Charlotte M Deane

Large scale paired antibody language models

大规模配对抗体语言模型

Kenlay, Henry; Dreyer, Frédéric A; Kovaltsuk, Aleksandr; Miketa, Dom; Pires, Douglas; Deane, Charlotte M

Integration of multiple epigenomic marks improves prediction of variant impact in saturation mutagenesis reporter assay

整合多种表观基因组标记可提高饱和诱变报告基因检测中变异影响的预测准确性。

Shigaki, Dustin; Adato, Orit; Adhikari, Aashish N; Dong, Shengcheng; Hawkins-Hooker, Alex; Inoue, Fumitaka; Juven-Gershon, Tamar; Kenlay, Henry; Martin, Beth; Patra, Ayoti; Penzar, Dmitry D; Schubach, Max; Xiong, Chenling; Yan, Zhongxia; Boyle, Alan P; Kreimer, Anat; Kulakovskiy, Ivan V; Reid, John; Unger, Ron; Yosef, Nir; Shendure, Jay; Ahituv, Nadav; Kircher, Martin; Beer, Michael A