Kennedy Matthew E相关文献与解析，生知库

Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human Primates.

可溶性 VCAM-1 可作为药效学脑脊液标志物，用于监测非人灵长类动物的 BACE2 活性

doi:10.1016/j.mcpro.2025.101012

Tschirner Sarah K, Zuchero Y Joy Yu, Getz Jennifer A, MÃ¼ller Stephan A, Nalbach Karsten, Kennedy Matthew E, Lewcock Joseph W, Lichtenthaler Stefan F

Microglial roles in Alzheimer's disease: An agent-based model to elucidate microglial spatiotemporal response to beta-amyloid

小胶质细胞在阿尔茨海默病中的作用：基于主体的模型阐明小胶质细胞对β-淀粉样蛋白的时空反应

期刊:Cpt-Pharmacometrics & Systems Pharmacology

影响因子:3

doi:10.1002/psp4.13095

Weathered, Catherine; Bardehle, Sophia; Yoon, Choya; Kumar, Niyanta; Leyns, Cheryl E G; Kennedy, Matthew E; Bloomingdale, Peter; Pienaar, Elsje

Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings

Gga3缺失和与晚发性阿尔茨海默病相关的GGA3罕见变异会引发轴突肿胀中BACE1的积累。

期刊:Science Translational Medicine

影响因子:14.6

doi:10.1126/scitranslmed.aba1871

Lomoio, Selene; Willen, Rachel; Kim, WonHee; Ho, Kevin Z; Robinson, Edward K; Prokopenko, Dmitry; Kennedy, Matthew E; Tanzi, Rudolph E; Tesco, Giuseppina

BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain

BACE抑制剂可导致阿尔茨海默病脑组织体积快速、局部性且非进行性减少。

期刊:Brain

影响因子:11.7

doi:10.1093/brain/awaa332

Sur, Cyrille; Kost, James; Scott, David; Adamczuk, Katarzyna; Fox, Nick C; Cummings, Jeffrey L; Tariot, Pierre N; Aisen, Paul S; Vellas, Bruno; Voss, Tiffini; Mahoney, Erin; Mukai, Yuki; Kennedy, Matthew E; Lines, Christopher; Michelson, David; Egan, Michael F

Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models

药理学抑制BACE可改善神经损伤和疾病模型中的轴突再生

期刊:Neurotherapeutics

影响因子:6.9

doi:10.1007/s13311-020-00852-3

Tallon, Carolyn; Marshall, Katherine L; Kennedy, Matthew E; Hyde, Lynn A; Farah, Mohamed H

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage

长期服用维鲁贝司他可抑制老年Tg2576-AβPPswe小鼠体内淀粉样蛋白的积累，且不诱发微出血

期刊:Journal of Alzheimers Disease

影响因子:3.1

doi:10.3233/JAD-170056

Villarreal, Stephanie; Zhao, Fuqiang; Hyde, Lynn A; Holder, Daniel; Forest, Thomas; Sondey, Marie; Chen, Xia; Sur, Cyrille; Parker, Eric M; Kennedy, Matthew E

发表日期：2017

文献求助收藏

Modeling amyloid plaque turnover dynamics improves characterization of drug effects

模拟淀粉样斑块周转动力学有助于更好地表征药物效应。

Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human Primates.

可溶性 VCAM-1 可作为药效学脑脊液标志物，用于监测非人灵长类动物的 BACE2 活性

Microglial roles in Alzheimer's disease: An agent-based model to elucidate microglial spatiotemporal response to beta-amyloid

小胶质细胞在阿尔茨海默病中的作用：基于主体的模型阐明小胶质细胞对β-淀粉样蛋白的时空反应

Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings

Gga3缺失和与晚发性阿尔茨海默病相关的GGA3罕见变异会引发轴突肿胀中BACE1的积累。

BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain

BACE抑制剂可导致阿尔茨海默病脑组织体积快速、局部性且非进行性减少。

Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models

药理学抑制BACE可改善神经损伤和疾病模型中的轴突再生

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage

长期服用维鲁贝司他可抑制老年Tg2576-AβPPswe小鼠体内淀粉样蛋白的积累，且不诱发微出血