日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex

拟南芥SPT-ORM1复合物结构分析揭示鞘脂稳态机制

Peng Liu, Tian Xie, Xinyue Wu, Gongshe Han, Sita D Gupta, Zike Zhang, Jian Yue, Feitong Dong, Kenneth Gable, Somashekarappa Niranjanakumari, Wanyuan Li, Lin Wang, Wenchen Liu, Ruifeng Yao, Edgar B Cahoon, Teresa M Dunn, Xin Gong

SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia

SPTSSA 变体会改变鞘脂合成并导致复杂的遗传性痉挛性截瘫

Siddharth Srivastava, Hagar Mor Shaked, Kenneth Gable, Sita D Gupta, Xueyang Pan, Niranjanakumari Somashekarappa, Gongshe Han, Payam Mohassel, Marc Gotkine, Elizabeth Doney, Paula Goldenberg, Queenie K G Tan, Yi Gong, Benjamin Kleinstiver, Brian Wishart, Heidi Cope, Claudia Brito Pires, Hannah Stutz

Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis

鞘脂合成过量导致的儿童肌萎缩侧索硬化症

Payam Mohassel, Sandra Donkervoort #, Museer A Lone #, Matthew Nalls #, Kenneth Gable #, Sita D Gupta #, A Reghan Foley, Ying Hu, Jonas Alex Morales Saute, Ana Lucila Moreira, Fernando Kok, Alessandro Introna, Giancarlo Logroscino, Christopher Grunseich, Alec R Nickolls, Naemeh Pourshafie, Sarah B N

The ORMDL/Orm-serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes

ORMDL/Orm-丝氨酸棕榈酰转移酶 (SPT) 复合物直接受神经酰胺调控:在分离膜中重建 SPT 调控

Deanna L Davis, Kenneth Gable, John Suemitsu, Teresa M Dunn, Binks W Wattenberg

Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

神经元中神经酰胺合酶 2 的异位表达可抑制神经酰胺合酶 1 缺乏引起的神经变性

Stefka D Spassieva, Xiaojie Ji, Ye Liu, Kenneth Gable, Jacek Bielawski, Teresa M Dunn, Erhard Bieberich, Lihong Zhao

Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration

由于丝氨酸棕榈酰转移酶小亚基 b 突变导致 20 碳长链碱基增多,从而导致神经退行性病变

Lihong Zhao, Stefka Spassieva, Kenneth Gable, Sita D Gupta, Lan-Ying Shi, Jieping Wang, Jacek Bielawski, Wanda L Hicks, Mark P Krebs, Juergen Naggert, Yusuf A Hannun, Teresa M Dunn, Patsy M Nishina

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast

神经毒性甘油磷酸胆碱通过改变酵母中的神经酰胺生物合成影响 PtdIns-4, 5-双磷酸和 TORC2 信号传导

Michael A Kennedy, Kenneth Gable, Karolina Niewola-Staszkowska, Susana Abreu, Anne Johnston, Linda J Harris, Fulvio Reggiori, Robbie Loewith, Teresa Dunn, Steffany A L Bennett, Kristin Baetz

A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity

丝氨酸棕榈酰转移酶活性位点的致病突变导致催化混乱

Kenneth Gable, Sita D Gupta, Gongshe Han, Somashekarappa Niranjanakumari, Jeffrey M Harmon, Teresa M Dunn

Tsc10p and FVT1: topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals

Tsc10p 和 FVT1:酵母和哺乳动物中长链碱基合成所需的拓扑不同的短链还原酶

Sita D Gupta, Kenneth Gable, Gongshe Han, Anna Borovitskaya, Luke Selby, Teresa M Dunn, Jeffrey M Harmon