日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dysregulation of hepatic one-carbon metabolism in classical homocystinuria: Implications of redox-sensitive DHFR repression and tetrahydrofolate depletion for pathogenesis and treatment

经典同型胱氨酸尿症中肝脏一碳代谢失调:氧化还原敏感的 DHFR 抑制和四氢叶酸耗竭对发病机制和治疗的影响

Kenneth N Maclean, Hua Jiang, Philip D Neill, Ryan R Chanin, K Joseph Hurt, David J Orlicky, Teodoro Bottiglieri, James R Roede, Sally P Stabler

Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice

恢复肝细胞中的 ER 应激反应蛋白 TDAG51 可减轻小鼠的 NAFLD

Tamana R Yousof, Celeste C Bouchard, Mihnea Alb, Edward G Lynn, Sárka Lhoták, Hua Jiang, Melissa MacDonald, Hui Li, Jae H Byun, Yumna Makda, Maria Athanasopoulos, Kenneth N Maclean, Nathan J Cherrington, Asghar Naqvi, Suleiman A Igdoura, Joan C Krepinsky, Gregory R Steinberg, Richard C Austin

Characterization of mitochondrial and metabolic alterations induced by trisomy 21 during neural differentiation

21三体综合征在神经分化过程中诱导的线粒体和代谢改变的特征分析

Kendra M Prutton ,John O Marentette ,Kenneth N Maclean ,James R Roede

Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21

氧化应激是 21 三体导致神经外胚层分化加速的候选机制

Kendra M Prutton, John O Marentette, Brice A Leifheit, Hector Esquer, Daniel V LaBarbera, Colin C Anderson, Kenneth N Maclean, James R Roede

Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis

胱硫醚γ-裂解酶通过谷胱甘肽稳态促进雌激素刺激的子宫动脉血流

Rachael Bok, Damian D Guerra, Ramón A Lorca, Sara A Wennersten, Peter S Harris, Abhishek K Rauniyar, Sally P Stabler, Kenneth N MacLean, James R Roede, Laura D Brown, K Joseph Hurt

Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism

21 三体综合征对线粒体功能和中心碳代谢产生轻微影响

Colin C Anderson, John O Marentette, Kendra M Prutton, Abhishek K Rauniyar, Julie A Reisz, Angelo D'Alessandro, Kenneth N Maclean, Laura M Saba, James R Roede

Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis

存在或不存在治疗的情况下胱硫醚β-合酶缺陷型同型胱氨酸尿症患者的肝脏多胺、叶酸和蛋氨酸循环代谢紊乱:对发病机制的可能影响

Kenneth N Maclean, Hua Jiang, Whitney N Phinney, Bailey M Mclagan, James R Roede, Sally P Stabler

Estrogen Regulates Local Cysteine Metabolism in Mouse Myometrium

雌激素调节小鼠子宫肌层局部半胱氨酸代谢

Damian D Guerra, Rachael Bok, Kelsey Breen, Vibhuti Vyas, Hua Jiang, Kenneth N MacLean, K Joseph Hurt

GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury

GDF10 阻断肝脏 PPARγ 激活以防止饮食引起的肝损伤

Khrystyna Platko, Paul F Lebeau, Jae Hyun Byun, Samantha V Poon, Emily A Day, Melissa E MacDonald, Nicholas Holzapfel, Aurora Mejia-Benitez, Kenneth N Maclean, Joan C Krepinsky, Richard C Austin

SNARE proteins rescue impaired autophagic flux in Down syndrome

SNARE 蛋白挽救唐氏综合症患者受损的自噬通量

Stefanos Aivazidis, Abhilasha Jain, Abhishek K Rauniyar, Colin C Anderson, John O Marentette, David J Orlicky, Kristofer S Fritz, Peter S Harris, David Siegel, Kenneth N Maclean, James R Roede