日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors

抗精神病药物阿立哌唑、布瑞哌唑和卡利拉嗪是脱靶呼吸链复合物 I 抑制剂

Rachel E Hardy, Injae Chung, Yizhou Yu, Samantha H Y Loh, Nobuhiro Morone, Clement Soleilhavoup, Marco Travaglio, Riccardo Serreli, Lia Panman, Kelvin Cain, Judy Hirst, Luis M Martins, Marion MacFarlane, Kenneth R Pryde

Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature

细胞形态分析可实现针对蛋白水解靶向嵌合体 (PROTAC) 表型特征的高通量筛选

Maria-Anna Trapotsi, Elizabeth Mouchet, Guy Williams, Tiziana Monteverde, Karolina Juhani, Riku Turkki, Filip Miljković, Anton Martinsson, Lewis Mervin, Kenneth R Pryde, Erik Müllers, Ian Barrett, Ola Engkvist, Andreas Bender, Kevin Moreau

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

鉴定抗癌化疗药物中针对线粒体呼吸复合物 I 的新型毒理团

Zoe A Stephenson, Robert F Harvey #, Kenneth R Pryde #, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy Eh Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

PINK1 可抑制反裂变机制,从而分离受损的线粒体,进行线粒体自噬

Kenneth R Pryde, Heather L Smith, Kai-Yin Chau, Anthony H V Schapira