日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis

Agr2相关的内质网应激促进黏附侵袭性大肠杆菌菌群失调,并触发CD103+树突状细胞IL-23依赖性回结肠炎。

Monica Viladomiu ,Manirath Khounlotham ,Belgin Dogan ,Svetlana F Lima ,Ahmed Elsaadi ,Emre Cardakli ,Jim G Castellanos ,Charles Ng ,Jeremy Herzog ,Alexi A Schoenborn ,Melissa Ellermann ,Bo Liu ,Shiying Zhang ,Ajay S Gulati ,R Balfour Sartor ,Kenneth W Simpson ,Steven M Lipkin ,Randy S Longman

Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation

克罗恩病中,黏附侵袭性大肠杆菌对丙二醇的代谢调节吞噬细胞,从而加剧肠道炎症。

Monica Viladomiu ,Maeva L Metz ,Svetlana F Lima ,Wen-Bing Jin ,Lance Chou ,Gretchen E Diehl ,Kenneth W Simpson ,Ellen J Scherl ,Randy S Longman

Dietary Fructose Alters the Composition, Localization, and Metabolism of Gut Microbiota in Association With Worsening Colitis

膳食果糖会改变肠道菌群的组成、定位和代谢,并加剧结肠炎

David C Montrose, Ryohei Nishiguchi, Srijani Basu, Hannah A Staab, Xi Kathy Zhou, Hanhan Wang, Lingsong Meng, Melanie Johncilla, Juan R Cubillos-Ruiz, Diana K Morales, Martin T Wells, Kenneth W Simpson, Shiying Zhang, Belgin Dogan, Chen Jiao, Zhangjun Fei, Akihiko Oka, Jeremy W Herzog, R Balfour Sar

Long-read sequencing to interrogate strain-level variation among adherent-invasive Escherichia coli isolated from human intestinal tissue

长读测序探究从人体肠道组织中分离的粘附侵袭性大肠杆菌的菌株水平变异

Jeremy Wang, Rachel M Bleich, Sandra Zarmer, Shiying Zhang, Belgin Dogan, Kenneth W Simpson, Janelle C Arthur

Short Chain Fatty Acids Modulate the Growth and Virulence of Pathosymbiont Escherichia coli and Host Response

短链脂肪酸调节致病共生大肠杆菌的生长和毒力以及宿主反应

Shiying Zhang, Belgin Dogan, Cindy Guo, Deepali Herlekar, Katrina Stewart, Ellen J Scherl, Kenneth W Simpson

A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells

对克罗恩病相关微生物代谢产物的筛选发现,抗坏血酸是一种新型的活化人T细胞代谢抑制剂。

Yu-Ling Chang ,Maura Rossetti ,Hera Vlamakis ,David Casero ,Gemalene Sunga ,Nicholas Harre ,Shelley Miller ,Romney Humphries ,Thaddeus Stappenbeck ,Kenneth W Simpson ,R Balfour Sartor ,Gary Wu ,James Lewis ,Frederic Bushman ,Dermot P B McGovern ,Nita Salzman ,James Borneman ,Ramnik Xavier ,Curtis Huttenhower ,Jonathan Braun

Murine Adherent and Invasive E. coli Induces Chronic Inflammation and Immune Responses in the Small and Large Intestines of Monoassociated IL-10-/- Mice Independent of Long Polar Fimbriae Adhesin A

小鼠粘附性和侵袭性大肠杆菌在单相关 IL-10-/- 小鼠的小肠和大肠中诱发慢性炎症和免疫反应,且不依赖于长极性菌毛粘附素 A

Julia M Schmitz, Susan L Tonkonogy, Belgin Dogan, Anna Leblond, Kristi J Whitehead, Sandra C Kim, Kenneth W Simpson, R Balfour Sartor

Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses

肠道菌群在CX3CR1+肠道单核吞噬细胞调节肠道T细胞反应中的关键作用

Myunghoo Kim ,Carolina Galan ,Andrea A Hill ,Wan-Jung Wu ,Hannah Fehlner-Peach ,Hyo Won Song ,Deborah Schady ,Matthew L Bettini ,Kenneth W Simpson ,Randy S Longman ,Dan R Littman ,Gretchen E Diehl

Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation

小鼠结肠镜引导夹取活检是评估宿主和管腔因素在结肠炎症中的作用的有用模型

David C Montrose, Xi K Zhou, Erin M McNally, Erika Sue, Hanhan Wang, Ryohei Nishiguchi, Akanksha Verma, Olivier Elemento, Kenneth W Simpson, Peiying Yang, Timothy Hla, Andrew J Dannenberg

IgA-coated E. coli enriched in Crohn's disease spondyloarthritis promote TH17-dependent inflammation

在克罗恩病和强直性脊柱炎中富集的IgA包被大肠杆菌可促进TH17依赖性炎症。

Monica Viladomiu ,Charles Kivolowitz ,Ahmed Abdulhamid ,Belgin Dogan ,Daniel Victorio ,Jim G Castellanos ,Viola Woo ,Fei Teng ,Nhan L Tran ,Andrew Sczesnak ,Christina Chai ,Myunghoo Kim ,Gretchen E Diehl ,Nadim J Ajami ,Joseph F Petrosino ,Xi K Zhou ,Sergio Schwartzman ,Lisa A Mandl ,Meira Abramowitz ,Vinita Jacob ,Brian Bosworth ,Adam Steinlauf ,Ellen J Scherl ,Hsin-Jung Joyce Wu ,Kenneth W Simpson ,Randy S Longman