Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers
鉴定出VVD-214/RO7589831,一种用于治疗MSI-High癌症的临床阶段共价变构WRN解旋酶抑制剂
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01805
Kikuchi, Shota; Green, Jason C; Rogness, Don C; Lam, Betty; Owyang, Zachary A; Malmstrom, Robert D; Tabatabaei, Ali; Snead, Aaron N; Hoffman, Melissa A; Bernard, Steffen M; Ashby, Paige; Lamb, Kelsey N; Horning, Benjamin D; Baltgalvis, Kristen A; Symons, Kent T; Glaza, Thomas A; Wu, Chu-Chiao; Song, Xiaodan; Pastuszka, Martha K; Sigler, John J; Pollock, Jonathan; Burgess, Laurence; Simon, Gabriel M; Patricelli, Matthew P; Weinstein, David S