日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial

长期使用gantenerumab治疗显性遗传性阿尔茨海默病的安全性和有效性:一项2/3期多中心、随机、双盲、安慰剂对照平台DIAN-TU试验的开放标签扩展研究

Bateman, Randall J; Li, Yan; McDade, Eric M; Llibre-Guerra, Jorge J; Clifford, David B; Atri, Alireza; Mills, Susan L; Santacruz, Anna M; Wang, Guoqiao; Supnet, Charlene; Benzinger, Tammie L S; Gordon, Brian A; Ibanez, Laura; Klein, Gregory; Baudler, Monika; Doody, Rachelle S; Delmar, Paul; Kerchner, Geoffrey A; Bittner, Tobias; Wojtowicz, Jakub; Bonni, Azad; Fontoura, Paulo; Hofmann, Carsten; Kulic, Luka; Hassenstab, Jason; Aschenbrenner, Andrew J; Perrin, Richard J; Cruchaga, Carlos; Renton, Alan E; Xiong, Chengjie; Goate, Alison A; Morris, John C; Holtzman, David M; Snider, B Joy; Mummery, Catherine; Brooks, William S; Wallon, David; Berman, Sarah B; Roberson, Erik; Masters, Colin L; Galasko, Douglas R; Jayadev, Suman; Sanchez-Valle, Rachel; Pariente, Jeremie; Kinsella, Justin; van Dyck, Christopher H; Gauthier, Serge; Hsiung, Ging-Yuek Robin; Masellis, Mario; Dubois, Bruno; Honig, Lawrence S; Jack, Clifford R; Daniels, Alisha; Aguillón, David; Allegri, Ricardo; Chhatwal, Jasmeer; Day, Gregory; Fox, Nick C; Huey, Edward; Ikeuchi, Takeshi; Jucker, Mathias; Lee, Jae-Hong; Levey, Allan I; Levin, Johannes; Lopera, Francisco; Roh, JeeHoon; Rosa-Neto, Pedro; Schofield, Peter R

Plasma Aβ(42)/Aβ(40) is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum

血浆Aβ(42)/Aβ(40)比值对早期脑淀粉样蛋白沉积敏感,并可预测阿尔茨海默病谱系中认知功能下降的风险。

Trelle, Alexandra N; Young, Christina B; Vossler, Hillary; Ramos Benitez, Javier; Cody, Karly A; Mendiola, Justin H; Swarovski, Michelle S; Guen, Yann Le; Feinstein, Igor; Butler, Robert R 3rd; Channappa, Divya; Romero, America; Park, Jennifer; Shahid-Besanti, Marian; Corso, Nicole K; Chau, Kelly; Smith, Amanda N; Skylar-Scott, Irina; Yutsis, Maya V; Fredericks, Carolyn A; Tian, Lu; Younes, Kyan; Kerchner, Geoffrey A; Deutsch, Gayle K; Davidzon, Guido A; Sha, Sharon J; Henderson, Victor W; Longo, Frank M; Greicius, Michael D; Wyss-Coray, Tony; Andreasson, Katrin I; Poston, Kathleen L; Wagner, Anthony D; Mormino, Elizabeth C; Wilson, Edward N

Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.

帕金森病的特征是维生素 B6 依赖性炎症犬尿氨酸通路功能障碍

Wilson Edward N, Umans Jacob, Swarovski Michelle S, Minhas Paras S, Mendiola Justin H, Midttun Øivind, Ulvik Arve, Shahid-Besanti Marian, Linortner Patricia, Mhatre Siddhita D, Wang Qian, Channappa Divya, Corso Nicole K, Tian Lu, Fredericks Carolyn A, Kerchner Geoffrey A, Plowey Edward D, Cholerton Brenna, Ueland Per M, Zabetian Cyrus P, Gray Nora E, Quinn Joseph F, Montine Thomas J, Sha Sharon J, Longo Frank M, Wolk David A, Chen-Plotkin Alice, Henderson Victor W, Wyss-Coray Tony, Wagner Anthony D, Mormino Elizabeth C, Aghaeepour Nima, Poston Kathleen L, Andreasson Katrin I

Diagnostic performance of plasma biomarkers for detecting amyloid co‐pathology in Neuronal α‐Synuclein Disease

血浆生物标志物在检测神经元α-突触核蛋白疾病中的淀粉样蛋白共病理方面的诊断性能

Raveendran, Arya; Gupta, Ashutosh; Lewis, Leslie E; Prabhu, Krishnananda; Moorkoth, Sudheer; Smith, Alena Marie; Lorkiewicz, Sara A; Montoliu‐Gaya, Laia; Wilson, Ted N; Ashton, Nicholas; Arslan, Burak; Plastini, Melanie J; Young, Christina B; Winer, Joseph R; Shahid, Marian; Vossler, Hillary; Ramirez, Veronica; Pan, Tianyu; Kerchner, Geoffrey A; Andreasson, Katrin I; Henderson, Victor W; Montine, Thomas J; Tian, Lu; Mormino, Elizabeth C; Zetterberg, Henrik; Poston, Kathleen L; Abdelnour, Carla

Synergistic effects of APOE ε4 and Alzheimer's pathology on the neural correlates of episodic remembering in cognitively unimpaired older adults

APOE ε4 和阿尔茨海默病理对认知功能正常老年人情景记忆神经关联的协同作用

Trelle, Alexandra N; Sheng, Jintao; Wilson, Edward N; Romero, America; Park, Jennifer; Deutsch, Gayle K; Sha, Sharon J; Greicius, Michael D; Andreasson, Katrin I; Kerchner, Geoffrey A; Mormino, Elizabeth C; Wagner, Anthony D

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial

长期使用gantenerumab治疗显性遗传性阿尔茨海默病的安全性和有效性:一项开放标签扩展的2/3期多中心、随机、双盲、安慰剂对照平台DIAN-TU试验

Bateman, Randall J; Li, Yan; McDade, Eric M; Llibre-Guerra, Jorge J; Clifford, David B; Atri, Alireza; Mills, Susan L; Santacruz, Anna M; Wang, Guoqiao; Supnet, Charlene; Benzinger, Tammie L S; Gordon, Brian A; Ibanez, Laura; Klein, Gregory; Baudler, Monika; Doody, Rachelle S; Delmar, Paul; Kerchner, Geoffrey A; Bittner, Tobias; Wojtowicz, Jakub; Bonni, Azad; Fontoura, Paulo; Hofmann, Carsten; Kulic, Luka; Hassenstab, Jason; Aschenbrenner, Andrew J; Perrin, Richard J; Cruchaga, Carlos; Renton, Alan E; Xiong, Chengjie; Goate, Alison A; Morris, John C; Holtzman, David M; Snider, B Joy; Mummery, Catherine; Brooks, William S; Wallon, David; Berman, Sarah B; Roberson, Erik; Masters, Colin L; Galasko, Douglas R; Jayadev, Suman; Sanchez-Valle, Rachel; Pariente, Jeremie; Kinsella, Justin; van Dyck, Christopher H; Gauthier, Serge; Robin Hsiung, Ging-Yuek; Masellis, Mario; Dubois, Bruno; Honig, Lawrence S; Jack, Clifford R; Daniels, Alisha; Aguillón, David; Allegri, Ricardo; Chhatwal, Jasmeer; Day, Gregory; Fox, Nick; Huey, Edward; Ikeuchi, Takeshi; Jucker, Mathias; Lee, Jae-Hong; Levey, Allan I; Levin, Johannes; Lopera, Francisco; Roh, JeeHoon; Rosa-Neto, Pedro; Schofield, Peter R

Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease

普拉西珠单抗可减缓快速进展型早期帕金森病患者的运动功能进展

Pagano, Gennaro; Taylor, Kirsten I; Anzures Cabrera, Judith; Simuni, Tanya; Marek, Kenneth; Postuma, Ronald B; Pavese, Nicola; Stocchi, Fabrizio; Brockmann, Kathrin; Svoboda, Hanno; Trundell, Dylan; Monnet, Annabelle; Doody, Rachelle; Fontoura, Paulo; Kerchner, Geoffrey A; Brundin, Patrik; Nikolcheva, Tania; Bonni, Azad

Sustained effect of prasinezumab on Parkinson's disease motor progression in the open-label extension of the PASADENA trial

在 PASADENA 试验的开放标签扩展研究中,普拉西珠单抗对帕金森病运动进展的持续疗效

Pagano, Gennaro; Monnet, Annabelle; Reyes, Adriana; Ribba, Benjamin; Svoboda, Hanno; Kustermann, Thomas; Simuni, Tanya; Postuma, Ronald B; Pavese, Nicola; Stocchi, Fabrizio; Brockmann, Kathrin; Smigorski, Krzysztof; Gerbaldo, Valentina; Fontoura, Paulo; Doody, Rachelle; Kerchner, Geoffrey A; Brundin, Patrik; Marek, Kenneth; Bonni, Azad; Nikolcheva, Tania

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease

对脑脊液、血浆和尿液进行全面的蛋白质组学分析,可鉴定出DDC和其他早期帕金森病生物标志物

Rutledge, Jarod; Lehallier, Benoit; Zarifkar, Pardis; Losada, Patricia Moran; Shahid-Besanti, Marian; Western, Dan; Gorijala, Priyanka; Ryman, Sephira; Yutsis, Maya; Deutsch, Gayle K; Mormino, Elizabeth; Trelle, Alexandra; Wagner, Anthony D; Kerchner, Geoffrey A; Tian, Lu; Cruchaga, Carlos; Henderson, Victor W; Montine, Thomas J; Borghammer, Per; Wyss-Coray, Tony; Poston, Kathleen L

Biologically defined neuronal synuclein disease as a tool to advance drug development

以生物学定义的神经元突触核蛋白疾病作为推进药物研发的工具

Pagano, Gennaro; Dam, Tien; Kerchner, Geoffrey A; Galpern, Wendy R; Biagioni, Milton; Karan, Rajesh; Jennings, Danna; Peterschmitt, M Judith; Nikolcheva, Tania; Brundin, Patrik