日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE

利用 XTABLE 研究肺鳞状细胞癌中通路功能障碍的癌前演变

Roberts, Matthew; Ogden, Julia; Hossain, A S Mukarram; Chaturvedi, Anshuman; Kerr, Alastair R W; Dive, Caroline; Beane, Jennifer Ellen; Lopez-Garcia, Carlos

A multistage sequencing strategy pinpoints novel candidate alleles for Emery-Dreifuss muscular dystrophy and supports gene misregulation as its pathomechanism

多阶段测序策略确定了埃默里-德雷福斯肌营养不良症的新候选等位基因,并支持基因失调是其发病机制的观点。

Meinke, Peter; Kerr, Alastair R W; Czapiewski, Rafal; de Las Heras, Jose I; Dixon, Charles R; Harris, Elizabeth; Kölbel, Heike; Muntoni, Francesco; Schara, Ulrike; Straub, Volker; Schoser, Benedikt; Wehnert, Manfred; Schirmer, Eric C

Analysis of RNA-Seq datasets reveals enrichment of tissue-specific splice variants for nuclear envelope proteins.

RNA-Seq 数据集分析显示,核膜蛋白存在组织特异性剪接变体的富集

Capitanchik Charlotte, Dixon Charles R, Swanson Selene K, Florens Laurence, Kerr Alastair R W, Schirmer Eric C

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments

T细胞活化过程中,核纤层相关增强子和基因从核膜受限释放,促进它们在染色体区室中的结合。

Robson, Michael I; de Las Heras, Jose I; Czapiewski, Rafal; Sivakumar, Aishwarya; Kerr, Alastair R W; Schirmer, Eric C

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer

肝癌中Tet1相关5-羟甲基胞嘧啶的缺失与异常启动子高甲基化同时发生

Thomson, John P; Ottaviano, Raffaele; Unterberger, Elif B; Lempiäinen, Harri; Muller, Arne; Terranova, Remi; Illingworth, Robert S; Webb, Shaun; Kerr, Alastair R W; Lyall, Marcus J; Drake, Amanda J; Wolf, C Roland; Moggs, Jonathan G; Schwarz, Michael; Meehan, Richard R

Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis

肌肉核膜蛋白介导的组织特异性基因重定位增强了肌生成过程中关键发育基因的抑制。

Robson, Michael I; de Las Heras, Jose I; Czapiewski, Rafal; Lê Thành, Phú; Booth, Daniel G; Kelly, David A; Webb, Shaun; Kerr, Alastair R W; Schirmer, Eric C

Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome

人脑DNA甲基化组的个体间差异与区域同质性形成鲜明对比

Illingworth, Robert S; Gruenewald-Schneider, Ulrike; De Sousa, Dina; Webb, Shaun; Merusi, Cara; Kerr, Alastair R W; James, Keith D; Smith, Colin; Walker, Robert; Andrews, Robert; Bird, Adrian P

Many mechanisms, one entrance: membrane protein translocation into the nucleus

多种机制,一个入口:膜蛋白转位进入细胞核

Zuleger, Nikolaj; Kerr, Alastair R W; Schirmer, Eric C

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

CpG岛通过CpG结合蛋白Cfp1影响染色质结构。

Thomson, John P; Skene, Peter J; Selfridge, Jim; Clouaire, Thomas; Guy, Jacky; Webb, Shaun; Kerr, Alastair R W; Deaton, Aimée; Andrews, Rob; James, Keith D; Turner, Daniel J; Illingworth, Robert; Bird, Adrian

Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state

神经元 MeCP2 的表达水平接近组蛋白八聚体水平,并能整体改变染色质状态。

Skene, Peter J; Illingworth, Robert S; Webb, Shaun; Kerr, Alastair R W; James, Keith D; Turner, Daniel J; Andrews, Rob; Bird, Adrian P