日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort

Insight 46:一项针对1946年英国出生队列的深入神经科学子研究的保留率和纵向变化

Keuss, Sarah E; Lu, Kirsty; James, Sarah-Naomi; Nicholas, Jennifer M; Coath, William; Keshavan, Ashvini; Cash, David M; Sudre, Carole H; Barnes, Josephine; Murray-Smith, Heidi; Wong, Andrew; Street, Rebecca; Richards, Marcus; Schott, Jonathan M

TDP-43 loss induces cryptic polyadenylation in ALS/FTD.

TDP-43 缺失导致 ALS/FTD 中出现隐蔽的多聚腺苷酸化。

Bryce-Smith Sam, Brown Anna-Leigh, Chien Max Z Y J, Dattilo Dario, Mehta Puja R, Mattedi Francesca, Barattucci Simone, Mikheenko Alla, Zanovello Matteo, Pellegrini Flaminia, El-Agamy Sara Emad, Yome Matthew, Hill Sarah E, Qi Yue A, Sun Kai, Ryadnov Eugeni, Wan Yixuan, Vargas Jose Norberto S, Birsa Nicol, Raj Towfique, Humphrey Jack, Keuss Matthew, Wilkins Oscar G, Ward Michael, Secrier Maria, Fratta Pietro

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.

TDP-43 依赖的 KCNQ2 错误剪接引发 ALS/FTD 中的内在神经元过度兴奋。

Joseph Brian J, Marshall Kelly A, Harley Peter, Mann Jacob R, Alessandrini Francesco, Vanoye Carlos G, Chi Wanhao, Prudencio Mercedes, Simkin Dina, Kao Tzu-Ting, Desai Reshma R, Keuss Matthew J, Barattucci Simone, Zanovello Matteo, Mehta Puja R, DeKeyser Jean-Marc, Limone Francesco, Lee Jonathan, Brown Anna-Leigh, Leyton-Jaimes Marcel F, Nash Leslie A, Juan Irune Guerra San, Aronica Eleonora, Wainger Brian J, Shah Mala, Goswami Anand, Shneider Neil A, Dickson Dennis W, Burrone Juan, Zhang Chaolin, Wichterle Hynek, Petrucelli Leonard, Watts Jonathan K, George Alfred L Jr, Fratta Pietro, Eggan Kevin, Kiskinis Evangelos

Altered mRNA transport and local translation in i3Neurons with RNA-binding protein knockdown

RNA结合蛋白敲低导致i3神经元中mRNA转运和局部翻译发生改变

Rachael Dargan ,Alla Mikheenko ,Nicholas L Johnson ,Benjamin E Packer ,Ziyi Li ,Emma J Craig ,Christina N Como ,Stephanie L Sarbanes ,Colleen Bereda ,Ying Hao ,Puja R Mehta ,Matthew Keuss ,Mike A Nalls ,Yue A Qi ,Cory A Weller ,Pietro Fratta ,Veronica H Ryan

Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults

老年人加速遗忘、淀粉样蛋白沉积和脑萎缩之间的关联

Lu, Kirsty; Baker, John; Nicholas, Jennifer M; Street, Rebecca E; Keuss, Sarah E; Coath, William; James, Sarah-Naomi; Keshavan, Ashvini; Weston, Philip S J; Murray-Smith, Heidi; Cash, David M; Malone, Ian B; Wong, Andrew; Fox, Nick C; Richards, Marcus; Crutch, Sebastian J; Schott, Jonathan M

Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging

一项基于人群的衰老研究发现,白质高信号体积增加与海马萎缩率相关

Brown, Thomas M; James, Sarah-Naomi; Nicholas, Jennifer M; Keuss, Sarah; Keshavan, Ashvini; Malone, Ian B; Coath, William; Murray-Smith, Heidi; Cash, David M; Barkhof, Frederik; Richards, Marcus; Schott, Jonathan M; Sudre, Carole H; Barnes, Josephine

Associations between night/shift working and late-life brain health

夜班/轮班工作与晚年大脑健康之间的关联

King-Robson, Josh; Nicholas, Jennifer M; James, Sarah-Naomi; Keshavan, Ashvini; Williams, Dylan M; Groves, James; Sudre, Carole H; Lu, Kirsty; Barnes, Josephine; Coath, William; Cash, David M; Keuss, Sarah E; Richards, Marcus; Warren, Jason D; Schott, Jonathan M

Sensitivity to TDP-43 loss and degradation resistance determine cryptic exon biomarker potential

对 TDP-43 丢失的敏感性和降解抵抗性决定了隐蔽外显子作为生物标志物的潜力。

Brown, Anna-Leigh; Zanovello, Matteo; Mikheenko, Alla; Dattilo, Dario; Pellegrini, Flaminia; Bryce-Smith, Sam; Mattedi, Francesca; Mehta, Puja R; Vargas, Jose Norberto S; Humphrey, Jack; Keuss, Matthew J; Fratta, Pietro

U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis.

U7 小核 RNA 剪接转换疗法用于治疗肌萎缩侧索硬化症中的 STMN2 和 UNC13A。

Mehta Puja R, Solomon Tomas, Pickles Sarah, Harley Peter, Barioglio Michela, Schweingruber Christoph, Marrero-Gagliardi Alessandro, Gao Yujing, Mattedi Francesca, Barattucci Simone, Lin Lilian Tsai-Wei, Ryadnov Eugeni, Zanovello Matteo, Cammack Alexander J, Isaacs Adrian M, Burrone Juan, Shaw Christopher E, Keuss Matthew J, Petrucelli Leonard, Fratta Pietro, Ruepp Marc-David

Creation of de novo cryptic splicing for ALS and FTD precision medicine

利用从头隐蔽剪接技术进行ALS和FTD精准医疗

Oscar G Wilkins ,Max Z Y J Chien # ,Josette J Wlaschin # ,Simone Barattucci ,Peter Harley ,Francesca Mattedi ,Puja R Mehta ,Maria Pisliakova ,Eugeni Ryadnov ,Matthew J Keuss ,David Thompson ,Holly Digby ,Lea Knez ,Rebecca L Simkin ,Juan Antinao Diaz ,Matteo Zanovello ,Anna-Leigh Brown ,Annalucia Darbey ,Rajvinder Karda ,Elizabeth M C Fisher ,Thomas J Cunningham ,Claire E Le Pichon ,Jernej Ule ,Pietro Fratta