Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
Brusatol 可快速、短暂地抑制 Nrf2 信号传导,并使哺乳动物细胞对化学毒性敏感 - 这对 Nrf2 治疗靶向性具有启示
期刊:Free Radical Biology and Medicine
影响因子:7.1
doi:10.1016/j.freeradbiomed.2014.11.003
Adedamola Olayanju, Ian M Copple, Holly K Bryan, George T Edge, Rowena L Sison, Min Wei Wong, Zheng-Quan Lai, Zhi-Xiu Lin, Karen Dunn, Christopher M Sanderson, Ahmad F Alghanem, Michael J Cross, Ewa C Ellis, Magnus Ingelman-Sundberg, Hassan Z Malik, Neil R Kitteringham, Christopher E Goldring, B Kev