Kevin D Read相关文献与解析，生知库 | 链接生命科学的每一步

Andreas Holmqvist #，Nur Mehpare Kocaturk #，Christina Duncan，Jennifer Riley，Steven Baginski，Graham Marsh，Joel Cresser-Brown，Hannah Maple，Kristiina Juvonen，Gajanan Sathe，Nicola Morrice，Calum Sutherland，Kevin D Read，William Farnaby

神经科学

GSK3

发表日期：2025

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Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform

使用高通量表型筛选平台鉴定可增强人类精子活力的化合物

期刊:Human Reproduction

影响因子:6

doi:10.1093/humrep/deac007

Franz S Gruber, Zoe C Johnston, Neil R Norcross, Irene Georgiou, Caroline Wilson, Kevin D Read, Ian H Gilbert, Jason R Swedlow, Sarah Martins da Silva, Christopher L R Barratt

Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials

脲取代2,4-二氨基嘧啶抗疟药的制备、生物学评价及QSAR分析

期刊:RSC Medicinal Chemistry

影响因子:4.1

doi:10.1039/d2md00218c

Borvornwat Toviwek, Jennifer Riley, Nicole Mutter, Mark Anderson, Lauren Webster, Irene Hallyburton, Duangkamol Gleeson, Kevin D Read, M Paul Gleeson

发表日期：2022

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A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

对非法药物市场上发现的吲哚和吲唑-3-酰胺合成大麻素受体激动剂的体外药代动力学和人体体内清除率进行系统研究

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules26051396

Andrew M Brandon, Lysbeth H Antonides, Jennifer Riley, Ola Epemolu, Denise A McKeown, Kevin D Read, Craig McKenzie

Targeting N-myristoylation for therapy of B-cell lymphomas

靶向 N-肉豆蔻酰化治疗 B 细胞淋巴瘤

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-020-18998-1

Erwan Beauchamp, Megan C Yap, Aishwarya Iyer, Maneka A Perinpanayagam, Jay M Gamma, Krista M Vincent, Manikandan Lakshmanan, Anandhkumar Raju, Vinay Tergaonkar, Soo Yong Tan, Soon Thye Lim, Wei-Feng Dong, Lynne M Postovit, Kevin D Read, David W Gray, Paul G Wyatt, John R Mackey, Luc G Berthiaume

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

CRMP2 O-GlcNAc 糖基化缺失导致小鼠新物体识别能力下降

期刊:Open Biology

影响因子:4.5

doi:10.1098/rsob.190192

Villo Muha, Ritchie Williamson, Rachel Hills, Alison D McNeilly, Thomas G McWilliams, Jana Alonso, Marianne Schimpl, Aneika C Leney, Albert J R Heck, Calum Sutherland, Kevin D Read, Rory J McCrimmon, Simon P Brooks, Daan M F van Aalten

信号转导

发表日期：2019

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Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

N-肉豆蔻酰转移酶作为杜氏利什曼原虫药物靶点的药理学验证

期刊:ACS Infectious Diseases

影响因子:4

doi:10.1021/acsinfecdis.8b00226

Victoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, Richard J Wall, Leah S Torrie, Dorothea Zander-Dinse, Michele Tinti, Stephen Brand, Laste Stojanovski, Sujatha Manthri, Irene Hallyburton, Fabio Zuccotto, Paul G Wyatt, Manu De Rycker, David Horn, Michael A J Ferguson, Joachim Clos, Kevin D Read,

信号转导

发表日期：2019

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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

基于基团的 von Hippel-Lindau (VHL) E3 泛素连接酶强效细胞活性抑制剂的优化：化学探针 (2S,4R)-1-((S)-2-(1-氰基环丙烷甲酰胺基)-3,3-二甲基丁酰基)-4-羟基-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-甲酰胺 (VH298) 的构效关系

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.7b00675

Pedro Soares, Morgan S Gadd, Julianty Frost, Carles Galdeano, Lucy Ellis, Ola Epemolu, Sonia Rocha, Kevin D Read, Alessio Ciulli

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

抗锥虫氨甲基苯并氧硼酸的宿主-寄生虫共代谢激活

期刊:PLoS Pathogens

影响因子:5.5

doi:10.1371/journal.ppat.1006850

Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C Del Pino, Isabel M Vincent, Yong-Kang Zhang, Yvonne R Freund, Michael R K Alley, Robert T Jacobs, Kevin D Read, Michael P Barrett, David Horn, Mark C Field

代谢

发表日期：2018

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Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users

合成阿片类药物 MT-45 及其新发现的氟化类似物 2F-MT-45 的化学合成、表征和体外和体内代谢，并在已知吸毒者的尿液样本中对代谢物进行确认

期刊:Forensic Toxicology

影响因子:2.8

doi:10.1007/s11419-018-0413-1

Craig McKenzie, Oliver B Sutcliffe, Kevin D Read, Paul Scullion, Ola Epemolu, Daniel Fletcher, Anders Helander, Olof Beck, Alexia Rylski, Lysbeth H Antonides, Jennifer Riley, Shannah A Smith, Niamh Nic Daeid

代谢

发表日期：2018

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Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening

利用正交反应连接子筛选发现一种具有中枢神经系统活性的GSK3降解剂

Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform

使用高通量表型筛选平台鉴定可增强人类精子活力的化合物

Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials

脲取代2,4-二氨基嘧啶抗疟药的制备、生物学评价及QSAR分析

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

对非法药物市场上发现的吲哚和吲唑-3-酰胺合成大麻素受体激动剂的体外药代动力学和人体体内清除率进行系统研究

Targeting N-myristoylation for therapy of B-cell lymphomas

靶向 N-肉豆蔻酰化治疗 B 细胞淋巴瘤

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

CRMP2 O-GlcNAc 糖基化缺失导致小鼠新物体识别能力下降

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

N-肉豆蔻酰转移酶作为杜氏利什曼原虫药物靶点的药理学验证

基于基团的 von Hippel-Lindau (VHL) E3 泛素连接酶强效细胞活性抑制剂的优化：化学探针 (2S,4R)-1-((S)-2-(1-氰基环丙烷甲酰胺基)-3,3-二甲基丁酰基)-4-羟基-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-甲酰胺 (VH298) 的构效关系

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

抗锥虫氨甲基苯并氧硼酸的宿主-寄生虫共代谢激活

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users

合成阿片类药物 MT-45 及其新发现的氟化类似物 2F-MT-45 的化学合成、表征和体外和体内代谢，并在已知吸毒者的尿液样本中对代谢物进行确认