日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities

通过克隆选择鉴定的针对 HER2 的 IgE 抗体通过免疫刺激活动限制乳腺癌的生长

Lais C G F Palhares #, Melanie Grandits #, Katie Stoker, Jitesh Chauhan, Heng Sheng Sow, Gilbert O Fruhwirth, Sophia Tsoka, James Birtley, Leanne Partington, Tim Wilson, Elizabeth Hardaker, Sophia N Karagiannis, Heather J Bax, Kevin FitzGerald

Social Isolation Activates Dormant Mammary Tumors, and Modifies Inflammatory and Mitochondrial Metabolic Pathways in the Rat Mammary Gland

社会隔离激活休眠乳腺肿瘤,并改变大鼠乳腺的炎症和线粒体代谢途径

Fabia de Oliveira Andrade, Lu Jin, Robert Clarke, Imani Wood, MaryAnn Dutton, Chezaray Anjorin, Grace Rubin, Audrey Gao, Surojeet Sengupta, Kevin FitzGerald, Leena Hilakivi-Clarke

Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis

高频膳食小鼠中肝脏特异性 FGFR4 敲低可增加胆汁酸合成并改善肝脏脂肪变性

Francois Moreau, Bruna Brasil Brunao, Xiang-Yu Liu, Frederic Tremblay, Kevin Fitzgerald, Julian Avila-Pacheco, Clary Clish, Ronald C Kahn, Samir Softic

NgAgo possesses guided DNA nicking activity

NgAgo 具有引导 DNA 切口活性

Kok Zhi Lee, Michael A Mechikoff, Archana Kikla, Arren Liu, Paula Pandolfi, Kevin Fitzgerald, Frederick S Gimble, Kevin V Solomon

Generation and validation of structurally defined antibody-siRNA conjugates

结构明确的抗体-siRNA偶联物的生成和验证

Alex R Nanna ,Alexander V Kel'in ,Christopher Theile ,Justin M Pierson ,Zhi Xiang Voo ,Ashish Garg ,Jayaprakash K Nair ,Martin A Maier ,Kevin Fitzgerald ,Christoph Rader

Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence

使用小分子抑制剂 FQI1 或 siRNA 靶向致癌基因 LSF 会导致有丝分裂延迟和染色体未对齐,从而导致细胞死亡或衰老

Jennifer L S Willoughby, Kelly George, Mark P Roberto, Hang Gyeong Chin, Patrick Stoiber, Hyunjin Shin, Chandra Sekhar Pedamallu, Scott E Schaus, Kevin Fitzgerald, Jagesh Shah, Ulla Hansen

Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

将计算机模拟心律失常风险检测与 tPKPD 模型相结合,预测麻醉豚鼠检测中的 QTc 间期延长

Pierre Morissette, Sebastian Polak, Anne Chain, Jin Zhai, John P Imredy, Mary Jo Wildey, Jeffrey Travis, Kevin Fitzgerald, Patrick Fanelli, Elisa Passini, Blanca Rodriguez, Frederick Sannajust, Christopher Regan

Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model

蛋白激酶 A (PKA) 信号的激活可减轻 Sur1-/- 小鼠模型中的先天性高胰岛素血症相关低血糖症

Mangala M Soundarapandian, Christine A Juliana, Jinghua Chai, Patrick A Haslett, Kevin Fitzgerald, Diva D De León

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

膳食糖通过线粒体蛋白的转录和翻译后修饰改变肝脏脂肪酸氧化

Samir Softic, Jesse G Meyer, Guo-Xiao Wang, Manoj K Gupta, Thiago M Batista, Hans P M M Lauritzen, Shiho Fujisaka, Dolors Serra, Laura Herrero, Jennifer Willoughby, Kevin Fitzgerald, Olga Ilkayeva, Christopher B Newgard, Bradford W Gibson, Birgit Schilling, David E Cohen, C Ronald Kahn

An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema

一项针对因子 XII (ALN-F12) 的在研 RNAi 疗法,用于治疗遗传性血管性水肿

Jingxuan Liu, June Qin, Anna Borodovsky, Timothy Racie, Adam Castoreno, Mark Schlegel, Martin A Maier, Tracy Zimmerman, Kevin Fitzgerald, James Butler, Akin Akinc