日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Imaging-Guided Evaluation of the Novel Small-Molecule Benzosuberene Tubulin-Binding Agent KGP265 as a Potential Therapeutic Agent for Cancer Treatment

影像引导下评估新型小分子苯并环庚烯微管蛋白结合剂 KGP265 作为癌症治疗的潜在治疗剂

Yihang Guo, Honghong Wang, Jeni L Gerberich, Samuel O Odutola, Amanda K Charlton-Sevcik, Maoping Li, Rajendra P Tanpure, Justin K Tidmore, Mary Lynn Trawick, Kevin G Pinney, Ralph P Mason, Li Liu

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia

可生物还原活化的 Combretastatin A-1 和 Combretastatin A-4 前药结合物作为针对肿瘤相关缺氧的抗癌剂

Blake A Winn, Laxman Devkota, Bunnarack Kuch, Matthew T MacDonough, Tracy E Strecker, Yifan Wang, Zhe Shi, Jeni L Gerberich, Deboprosad Mondal, Alejandro J Ramirez, Ernest Hamel, David J Chaplin, Peter Davis, Ralph P Mason, Mary Lynn Trawick, Kevin G Pinney

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization

结构引导设计、合成和新型苯并环庚烯类似物作为微管蛋白聚合抑制剂的生物学评价

Haichan Niu, Tracy E Strecker, Jeni L Gerberich, James W Campbell 3rd, Debabrata Saha, Deboprosad Mondal, Ernest Hamel, David J Chaplin, Ralph P Mason, Mary Lynn Trawick, Kevin G Pinney

The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts

OXi8006 在内皮细胞中的血管破坏活性及其磷酸盐前药 OXi8007 在乳腺肿瘤异种移植中的血管破坏活性

Tracy E Strecker, Samuel O Odutola, Ramona Lopez, Morgan S Cooper, Justin K Tidmore, Amanda K Charlton-Sevcik, Li Li, Matthew T MacDonough, Mallinath B Hadimani, Anjan Ghatak, Li Liu, David J Chaplin, Ralph P Mason, Kevin G Pinney, Mary Lynn Trawick

Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L

苯甲酰二苯甲酮缩氨基硫脲类似物作为蛋白酶 L 的有效和选择性抑制剂的合成及生化评价

Erica N Parker, Jiangli Song, G D Kishore Kumar, Samuel O Odutola, Gustavo E Chavarria, Amanda K Charlton-Sevcik, Tracy E Strecker, Ashleigh L Barnes, Dhivya R Sudhan, Thomas R Wittenborn, Dietmar W Siemann, Michael R Horsman, David J Chaplin, Mary Lynn Trawick, Kevin G Pinney

Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents

McMurry 偶联反应在合成三芳基乙烯和四芳基乙烯类似物作为潜在癌症化疗药物中的应用

Rajendra P Tanpure, Amanda R Harkrider, Tracy E Strecker, Ernest Hamel, Mary Lynn Trawick, Kevin G Pinney