日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4

BLIMP1 通过调控细胞周期进程和关键转录因子 BCL6 和 IRF4 来控制生发中心 B 细胞的扩增和退出。

Laura Conter,Shuchi Smita,Derrick Callahan,Shuxian Wu,Aiden Brown,Kevin M Nickerson,Rebecca A Elsner,Wenzhao Meng,Ayelet Peres,Gur Yaari,Steven H Kleinstein,Eline T Luning Prak,Wei Luo,Mark Shlomchik

BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4

BLIMP1 通过调控细胞周期进程和关键转录因子 BCL6 和 IRF4 来控制生发中心 B 细胞的扩增和退出。

Laura Conter ,Shuchi Smita ,Derrick Callahan ,Shuxian Wu ,Aiden Brown ,Kevin M Nickerson ,Rebecca A Elsner ,Wenzhao Meng ,Ayelet Peres ,Gur Yaari ,Steven H Kleinstein ,Eline T Luning Prak ,Wei Luo ,Mark Shlomchik

Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice

与年龄相关的 B 细胞是小鼠自身免疫的异质性和动态驱动因素

Kevin M Nickerson, Shuchi Smita, Kenneth B Hoehn, Anthony D Marinov, Kayla B Thomas, Justin T Kos, Yi Yang, Sheldon I Bastacky, Corey T Watson, Steven H Kleinstein, Mark J Shlomchik

Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus

TLR9 的基因解析揭示了小鼠狼疮中复杂的调控和隐秘的促炎作用

Claire Leibler, Shinu John, Rebecca A Elsner, Kayla B Thomas, Shuchi Smita, Stephen Joachim, Russell C Levack, Derrick J Callahan, Rachael A Gordon, Sheldon Bastacky, Ryutaro Fukui, Kensuke Miyake, Sebastien Gingras, Kevin M Nickerson, Mark J Shlomchik

The Type II Anti-CD20 Antibody Obinutuzumab (GA101) Is More Effective Than Rituximab at Depleting B Cells and Treating Disease in a Murine Lupus Model

II 型抗 CD20 抗体 Obinutuzumab (GA101) 在小鼠狼疮模型中比利妥昔单抗更有效地消耗 B 细胞并治疗疾病

Anthony D Marinov, Haowei Wang, Sheldon I Bastacky, Erwin van Puijenbroek, Thomas Schindler, Dario Speziale, Mario Perro, Christian Klein, Kevin M Nickerson, Mark J Shlomchik

cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE

cGAS-STING 通路不会促进小鼠 SLE 模型中的自身免疫

Mona Motwani, Jason McGowan, Jennifer Antonovitch, Kevin MingJie Gao, Zhaozhao Jiang, Shruti Sharma, Gretchen A Baltus, Kevin M Nickerson, Ann Marshak-Rothstein, Katherine A Fitzgerald

Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model

在 MRL.Faslpr 模型中,小鼠狼疮不依赖中性粒细胞弹性蛋白酶

Rachael A Gordon, Jeremy S Tilstra, Anthony Marinov, Kevin M Nickerson, Sheldon I Bastacky, Mark J Shlomchik

Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions

IL-21 和 IL-4 在生发中心 B 细胞分阶段启动和随后的自我更新转变中的非冗余作用

David G Gonzalez, Christine M Cote, Jaymin R Patel, Colin B Smith, Yuqi Zhang, Kevin M Nickerson, Tingting Zhang, Steven M Kerfoot, Ann M Haberman

B Cell-Extrinsic Myd88 and Fcer1g Negatively Regulate Autoreactive and Normal B Cell Immune Responses

细胞外源性 Myd88 和 Fcer1g 负向调节自身反应性和正常 B 细胞免疫反应

Rebecca A Sweet, Kevin M Nickerson, Jaime L Cullen, Yujuan Wang, Mark J Shlomchik

TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation

TLR9 通过限制无能抗 DNA B 细胞的存活来促进耐受性,但也是其激活所必需的

Kevin M Nickerson, Sean R Christensen, Jaime L Cullen, Wenzhao Meng, Eline T Luning Prak, Mark J Shlomchik