日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Optimizing the regularization in size-consistent second-order Brillouin-Wigner perturbation theory

优化尺寸一致的二阶布里渊-维格纳微扰理论中的正则化

Carter-Fenk, Kevin; Shee, James; Head-Gordon, Martin

Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer

雌激素疗法诱导未折叠蛋白反应,导致 ER+ 乳腺癌细胞死亡

Sarah R Hosford, Kevin Shee, Jason D Wells, Nicole A Traphagen, Jennifer L Fields, Riley A Hampsch, Arminja N Kettenbach, Eugene Demidenko, Todd W Miller

Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer

细胞因子敏感性筛选突出了 BMP4 通路信号传导作为 ER+ 乳腺癌的治疗机会

Kevin Shee, Amanda Jiang, Frederick S Varn, Stephanie Liu, Nicole A Traphagen, Philip Owens, Cynthia X Ma, Jeremy Hoog, Chao Cheng, Todd R Golub, Ravid Straussman, Todd W Miller

The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53

姜黄素类似物 HO-3867 通过将突变 p53 蛋白转化为转录活性野生型 p53 来选择性杀死癌细胞

Esha Madan, Taylor M Parker, Matthias R Bauer, Alisha Dhiman, Christopher J Pelham, Masaki Nagane, M Lakshmi Kuppusamy, Matti Holmes, Thomas R Holmes, Kranti Shaik, Kevin Shee, Salome Kiparoidze, Sean D Smith, Yu-Soon A Park, Jennifer J Gomm, Louise J Jones, Ana R Tomás, Ana C Cunha, Karuppaiyah Sel

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer

对 Rac GTPase 抑制的治疗敏感性需要乳腺癌中 mTORC1、AKT 和 MEK 信号传导的相应抑制

Riley A Hampsch, Kevin Shee, Darcy Bates, Lionel D Lewis, Laurent Désiré, Bertrand Leblond, Eugene Demidenko, Kurtis Stefan, Yina H Huang, Todd W Miller

The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer

PI3K/mTOR 双重抑制剂 P7170 显示出对内分泌敏感和内分泌抗性 ER+ 乳腺癌的强效活性

Jennifer R Bean, Sarah R Hosford, Lynn K Symonds, Philip Owens, Lloye M Dillon, Wei Yang, Kevin Shee, Gary N Schwartz, Jonathan D Marotti, Kristen E Muller, Kari M Rosenkranz, Richard J Barth, Vivian S Chen, Veena R Agarwal, Todd W Miller

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

肿瘤微环境通过 HGF 分泌引发对 RAF 抑制剂的先天抗性

Ravid Straussman, Teppei Morikawa, Kevin Shee, Michal Barzily-Rokni, Zhi Rong Qian, Jinyan Du, Ashli Davis, Margaret M Mongare, Joshua Gould, Dennie T Frederick, Zachary A Cooper, Paul B Chapman, David B Solit, Antoni Ribas, Roger S Lo, Keith T Flaherty, Shuji Ogino, Jennifer A Wargo, Todd R Golub