日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

CDK2抑制剂BLU-222通过诱导p21/p27与CDK4/6抑制剂协同作用,治疗耐药性乳腺癌。

Luo, Linjie; Wang, Yan; Bui, Tuyen; Jiang, Xiaoting; Chen, Mei-Kuang; Rao, Xiayu; Mohammadhosseinpour, Sepideh; Li, Mi; Kim, Serena; Kim, Rachel Y; Kamaliasl, Saba; Ulizio, Carmen W; Tsavachidis, Spyros; Navarro-Yepes, Juliana; Kettner, Nicole M; Wingate, Hannah; Meric-Bernstam, Funda; Hunt, Kelly K; Wang, Jing; Faia, Kerrie; Keyomarsi, Khandan

Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer.

单细胞 RNA 测序可识别预测 HR+/HER2-转移性乳腺癌患者 CDK4/6 抑制剂治疗后期进展的分子生物标志物

Luo Linjie, Yang Peng, Mastoraki Sofia, Rao Xiayu, Wang Yan, Kettner Nicole M, Raghavendra Akshara Singareeka, Tripathy Debasish, Damodaran Senthil, Hunt Kelly K, Wang Jing, Li Ziyi, Keyomarsi Khandan

FGFR3-induced Y158 PARP1 phosphorylation promotes PARP inhibitor resistance via BRG1/MRE11-mediated DNA repair in breast cancer models

在乳腺癌模型中,FGFR3诱导的Y158 PARP1磷酸化通过BRG1/MRE11介导的DNA修复促进PARP抑制剂耐药性

Chen, Mei-Kuang; Yamaguchi, Hirohito; Gao, Yuan; Xia, Weiya; Chang, Jeffrey T; Hsiao, Yu-Chun; Shegute, Tewodros W; Lin, Zong-Shin; Wu, Chen-Shiou; Wang, Yu-Han; Litton, Jennifer K; Ding, Qingqing; Wei, Yongkun; Chu, Yu-Yi; Meric-Bernstam, Funda; Piwnica-Worms, Helen; Arun, Banu; Rodon Ahnert, Jordi; Liu, Jinsong; Yao, Jun; Chang, Wei-Chao; Wang, Hung-Ling; Tapia, Coya; Albarracin, Constance T; Keyomarsi, Khandan; Wang, Shao-Chun; Wang, Ying-Nai; Hortobagyi, Gabriel N; Lin, Chunru; Yang, Liuqing; Yu, Dihua; Hung, Mien-Chie

IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer.

IL-6 预测 CDK4/6 抑制剂耐药性,确定 STAT3 为 HR+/HER2 阴性转移性乳腺癌的靶点

Kettner Nicole M, Bui Tuyen N, Navarro-Yepes Juliana, Ghotbaldini Sanaz, Quintela Bethanie, Luo Catherine K, Lam Nghi, Rao Xiayu, Raghavendra Akshara Singareeka, Wang Yan, Azizian Nancy, Kris Eckols T, Kasembeli Moses Makokha, Evans Kurt, Yi Min, Wingate Hannah, Wang Jing, Sahin Aysegul A, Meric-Bernstam Funda, Hunt Kelly K, Damodaran Senthil, Tweardy David J, Tripathy Debu, Keyomarsi Khandan

Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2- breast cancer

羟氯喹增强哌柏西利和来曲唑对 ER+/HER2- 乳腺癌疗效的 I 期试验

Akshara Singareeka Raghavendra, Nicole M Kettner, Danielle Kwiatkowski, Senthil Damodaran, Yan Wang, David Ramirez, Dan S Gombos, Kelly K Hunt, Yu Shen, Khandan Keyomarsi, Debu Tripathy

Targeting CDK2 and other novel cell cycle targets for breast cancer therapy

以 CDK2 和其他新型细胞周期靶点为靶点的乳腺癌治疗

Chen, Mei-Kuang; Luo, Linjie; Massoumi, Nicole; Keyomarsi, Khandan

Low-Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer.

低分子量细胞周期蛋白 E 使三阴性乳腺癌对 PKMYT1 抑制剂敏感

Li Mi, Lulla Amriti R, Wang Yan, Tsavaschidis Spyros, Wang Fuchenchu, Karakas Cansu, Nguyen Tuyen D T, Bui Tuyen N, Pina Marc A, Chen Mei-Kuang, Mastoraki Sofia, Multani Asha S, Fowlkes Natalie W, Sahin Aysegul, Marshall C Gary, Hunt Kelly K, Keyomarsi Khandan

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

细胞周期阻滞诱导脂滴形成并赋予细胞铁死亡抵抗力。

Hyemin Lee,Amber Horbath,Lavanya Kondiparthi,Jitendra Kumar Meena,Guang Lei,Shayani Dasgupta,Xiaoguang Liu,Li Zhuang,Pranavi Koppula,Mi Li,Iqbal Mahmud,Bo Wei,Philip L Lorenzi,Khandan Keyomarsi,Masha V Poyurovsky,Kellen Olszewski,Boyi Gan

STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response

STAT3 通过阻止有害的自分泌 I 型干扰素反应的激活来保护造血干细胞。

Patel, Bhakti; Zhou, Yifan; Babcock, Rachel L; Ma, Feiyang; Zal, M Anna; Kumar, Dhiraj; Medik, Yusra B; Kahn, Laura M; Pineda, Josué E; Park, Elizabeth M; Schneider, Sarah M; Tang, Ximing; Raso, Maria Gabriela; Jeter, Collene R; Zal, Tomasz; Clise-Dwyer, Karen; Keyomarsi, Khandan; Giancotti, Filippo G; Colla, Simona; Watowich, Stephanie S

Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis

中性粒细胞弹性蛋白酶重塑乳腺肿瘤以促进肺转移

Amriti R Lulla ,Said Akli ,Cansu Karakas ,Joseph A Caruso ,Lucas D Warma ,Natalie W Fowlkes ,Xiayu Rao ,Jing Wang ,Kelly K Hunt ,Stephanie S Watowich ,Khandan Keyomarsi