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Chondrogenic potential of mesenchymal progenitors from somatic and cartilage-derived iPSCs is predicted by their transcriptomic signatures

体细胞和软骨来源的iPSCs间充质祖细胞的软骨形成潜能可通过其转录组特征进行预测。

期刊:Genes and Diseases

影响因子:

doi:10.1016/j.gendis.2025.101730

Khan, Nazir M; Doan, Thanh N; Kaiser, Jarred M; Drissi, Hicham

细胞生物学

发表日期：2026

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Joint Acidosis and Acid-Sensing Receptors and Ion Channels in Osteoarthritis Pathobiology and Therapy

骨关节炎病理生物学与治疗中的关节酸中毒、酸敏感受体和离子通道

期刊:Cells

影响因子:5.2

doi:10.3390/cells14201605

Martin, William N; Hyde, Colette; Yung, Adam; Taffe, Ryan; Patel, Bhakti; Premkumar, Ajay; Bhattaram, Pallavi; Drissi, Hicham; Khan, Nazir M

Comparative transcriptomic analysis identifies distinct molecular signatures and regulatory networks of chondroclasts and osteoclasts

比较转录组分析揭示了软骨细胞和破骨细胞独特的分子特征和调控网络

期刊:Arthritis Research & Therapy

影响因子:4.6

doi:10.1186/s13075-020-02259-z

Khan, Nazir M; Clifton, Kari B; Lorenzo, Joseph; Hansen, Marc F; Drissi, Hicham

Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells

单细胞RNA测序揭示了人髓核和纤维环细胞独特的转录组图谱

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-020-72261-7

Fernandes, Lorenzo M; Khan, Nazir M; Trochez, Camila M; Duan, Meixue; Diaz-Hernandez, Martha E; Presciutti, Steven M; Gibson, Greg; Drissi, Hicham

Network Analysis Identifies Gene Regulatory Network Indicating the Role of RUNX1 in Human Intervertebral Disc Degeneration

网络分析揭示基因调控网络，表明RUNX1在人类椎间盘退变中发挥作用

期刊:Genes

影响因子:2.8

doi:10.3390/genes11070771

Khan, Nazir M; Diaz-Hernandez, Martha E; Presciutti, Steven M; Drissi, Hicham

Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics

表观遗传学在骨关节炎中的作用：HDAC抑制剂作为治疗药物的潜力

期刊:Pharmacological Research

影响因子:10.5

doi:10.1016/j.phrs.2017.08.007

Khan, Nazir M; Haqqi, Tariq M

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.

黄芩苷是一种植物来源的小分子，它通过激活人类骨关节炎软骨细胞中的 ROS/ERK/Nrf2 信号通路，发挥强大的抗炎和软骨保护作用

期刊:Free Radical Biology and Medicine

影响因子:8.2

doi:10.1016/j.freeradbiomed.2017.02.041

Khan Nazir M, Haseeb Abdul, Ansari Mohammad Y, Devarapalli Pratap, Haynie Sara, Haqqi Tariq M

A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-κB and IL-6 Expression by Blocking the Activation of IKKβ and NIK in Primary Human Chondrocytes

富含多酚的石榴果实提取物通过阻断原代人软骨细胞中IKKβ和NIK的激活来抑制NF-κB和IL-6的表达

期刊:Phytotherapy Research

影响因子:6.3

doi:10.1002/ptr.5799

Haseeb, Abdul; Khan, Nazir M; Ashruf, Omer S; Haqqi, Tariq M

A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1Î²-induced activation of AP-1 in human OA chondrocytes.

黄芩根提取物中富含黄芩苷的组分通过抑制IL-1β诱导的人类OA软骨细胞中AP-1的活化发挥软骨保护作用

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/srep43789

Khan Nazir M, Haseeb Abdul, Ansari Mohammad Y, Haqqi Tariq M

Joint Acidosis and GPR68 Signaling in Osteoarthritis: Implications for Cartilage Gene Regulation

骨关节炎中的关节酸中毒和GPR68信号通路：对软骨基因调控的影响

Chondrogenic potential of mesenchymal progenitors from somatic and cartilage-derived iPSCs is predicted by their transcriptomic signatures

体细胞和软骨来源的iPSCs间充质祖细胞的软骨形成潜能可通过其转录组特征进行预测。

Joint Acidosis and Acid-Sensing Receptors and Ion Channels in Osteoarthritis Pathobiology and Therapy

骨关节炎病理生物学与治疗中的关节酸中毒、酸敏感受体和离子通道

Comparative transcriptomic analysis identifies distinct molecular signatures and regulatory networks of chondroclasts and osteoclasts

比较转录组分析揭示了软骨细胞和破骨细胞独特的分子特征和调控网络

Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells

单细胞RNA测序揭示了人髓核和纤维环细胞独特的转录组图谱

Network Analysis Identifies Gene Regulatory Network Indicating the Role of RUNX1 in Human Intervertebral Disc Degeneration

网络分析揭示基因调控网络，表明RUNX1在人类椎间盘退变中发挥作用

Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics

表观遗传学在骨关节炎中的作用：HDAC抑制剂作为治疗药物的潜力

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.

黄芩苷是一种植物来源的小分子，它通过激活人类骨关节炎软骨细胞中的 ROS/ERK/Nrf2 信号通路，发挥强大的抗炎和软骨保护作用

A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-κB and IL-6 Expression by Blocking the Activation of IKKβ and NIK in Primary Human Chondrocytes

富含多酚的石榴果实提取物通过阻断原代人软骨细胞中IKKβ和NIK的激活来抑制NF-κB和IL-6的表达

A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1Î²-induced activation of AP-1 in human OA chondrocytes.

黄芩根提取物中富含黄芩苷的组分通过抑制IL-1β诱导的人类OA软骨细胞中AP-1的活化发挥软骨保护作用