日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tetrameric hotdog-fold structure and catalytic mechanism of the SaPaaI thioesterase from Staphylococcus aureus

金黄色葡萄球菌SaPaaI硫酯酶的四聚体热狗折叠结构和催化机制

Khandokar, Yogesh; Srivastava, Parul; Schwab, Renate H M; Sethi, Ashish; Vankadari, Naveen; Forwood, Jade K

Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target

天然产物介导的反应劫持机制证实了疟原虫天冬氨酰tRNA合成酶作为抗疟药物靶点的有效性

Ketprasit, Nutpakal; Tai, Chia-Wei; Sharma, Vivek Kumar; Manickam, Yogavel; Khandokar, Yogesh; Ye, Xi; Dogovski, Con; Hilko, David H; Morton, Craig J; Braun, Anne-Sophie C; Leeming, Michael G; Siddharam, Bagale; Shami, Gerald J; Pradeepkumar, Pushpangadan Indira; Panjikar, Santosh; Poulsen, Sally-Ann; Griffin, Michael D W; Sharma, Amit; Tilley, Leann; Xie, Stanley C

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

一种强效且选择性的恶性疟原虫酪氨酸 tRNA 合成酶反应劫持抑制剂在体内表现出单剂量口服疗效

Xie Stanley C, Tai Chia-Wei, Morton Craig J, Ma Liting, Huang Shih-Chung, Wittlin Sergio, Du Yawei, Hu Yongbo, Dogovski Con, Salimimarand Mina, Griffin Robert, England Dylan, de la Cruz Elisa, Deni Ioanna, Yeo Tomas, Burkhard Anna Y, Striepen Josefine, Schindler Kyra A, Crespo Benigno, Gamo Francisco J, Khandokar Yogesh, Hutton Craig A, Rabie Tayla, Birkholtz Lyn-Marié, Famodimu Mufuliat T, Delves Michael J, Bolsher Judith, Koolen Karin M J, van der Laak Rianne, Aguiar Anna C C, Pereira Dhelio B, Guido Rafael V C, Creek Darren J, Fidock David A, Dick Lawrence R, Brand Stephen L, Gould Alexandra E, Langston Steven, Griffin Michael D W, Tilley Leann

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function

CD1d2 和 CD1d1 蛋白在 I 型自然杀伤 T 细胞发育和功能中的不同作用

Sundararaj, Srinivasan; Zhang, Jingjing; Krovi, S Harsha; Bedel, Romain; Tuttle, Kathryn D; Veerapen, Natacha; Besra, Gurdyal S; Khandokar, Yogesh; Praveena, T; Le Nours, Jérôme; Matsuda, Jennifer L; Rossjohn, Jamie; Gapin, Laurent

Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase

细菌酰基辅酶A硫酯酶GDP介导调控的结构解析

Khandokar, Yogesh B; Srivastava, Parul; Cowieson, Nathan; Sarker, Subir; Aragao, David; Das, Shubagata; Smith, Kate M; Raidal, Shane R; Forwood, Jade K

Structural and Functional Characterization of the PaaI Thioesterase from Streptococcus pneumoniae Reveals a Dual Specificity for Phenylacetyl-CoA and Medium-chain Fatty Acyl-CoAs and a Novel CoA-induced Fit Mechanism

肺炎链球菌 PaaI 硫酯酶的结构和功能表征揭示了其对苯乙酰辅酶A和中链脂肪酰辅酶A的双重特异性以及一种新型的辅酶A诱导的契合机制。

Khandokar, Yogesh B; Srivastava, Parul; Sarker, Subir; Swarbrick, Crystall M D; Aragao, David; Cowieson, Nathan; Forwood, Jade K

Structural characterization of a Gcn5-related N-acetyltransferase from Staphylococcus aureus

金黄色葡萄球菌中 Gcn5 相关 N-乙酰转移酶的结构表征

Srivastava, Parul; Khandokar, Yogesh B; Swarbrick, Crystall M D; Roman, Noelia; Himiari, Zainab; Sarker, Subir; Raidal, Shane R; Forwood, Jade K

Purification, crystallization and preliminary X-ray diffraction analysis of the N-acetyltransferase SAV0826 from Staphylococcus aureus

金黄色葡萄球菌N-乙酰转移酶SAV0826的纯化、结晶和初步X射线衍射分析

Srivastava, Parul; Khandokar, Yogesh B; Forwood, Jade K

Expression, purification, crystallization and preliminary X-ray analysis of the PaaI-like thioesterase SAV0944 from Staphylococcus aureus

金黄色葡萄球菌 PaaI 样硫酯酶 SAV0944 的表达、纯化、结晶和初步 X 射线分析

Khandokar, Yogesh B; Roman, Noelia; Smith, Kate M; Srivastava, Parul; Forwood, Jade K

Expression, purification and crystallization of acetyl-CoA hydrolase from Neisseria meningitidis

脑膜炎奈瑟菌乙酰辅酶A水解酶的表达、纯化和结晶

Khandokar, Yogesh B; Londhe, Avinash; Patil, Shilpa; Forwood, Jade K