日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Another Kid on the Block: Long-acting FGF21 Analogue to Treat Dyslipidemia and Fatty Liver

又一款新药问世:长效FGF21类似物用于治疗血脂异常和脂肪肝

Yang, Ranyao; Xu, Aimin; Kharitonenkov, Alexei

FGF19 and FGF21: In NASH we trust

FGF19 和 FGF21:在 NASH 中,我们信赖它们

Talukdar, Saswata; Kharitonenkov, Alexei

Withdrawal: Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression

撤退:慢性营养不良期间成纤维细胞生长因子21 (FGF21) 表达增加,通过诱导瘦素受体重叠转录物 (LEPROT) 和瘦素受体重叠转录物样1 (LEPROTL1) 的表达,导致软骨细胞对生长激素不敏感。

Wu, Shufang; Grunwald, Tal; Kharitonenkov, Alexei; Dam, Julie; Jockers, Ralf; Luca, Francesco De

Interplay between FGF21 and insulin action in the liver regulates metabolism

FGF21与胰岛素在肝脏中的相互作用调节代谢

Emanuelli, Brice; Vienberg, Sara G; Smyth, Graham; Cheng, Christine; Stanford, Kristin I; Arumugam, Manimozhiyan; Michael, Mervyn D; Adams, Andrew C; Kharitonenkov, Alexei; Kahn, C Ronald

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

小鼠体内解偶联蛋白1基因的遗传破坏使得棕色脂肪组织成为FGF21分泌的重要来源。

Keipert, Susanne; Kutschke, Maria; Lamp, Daniel; Brachthäuser, Laura; Neff, Frauke; Meyer, Carola W; Oelkrug, Rebecca; Kharitonenkov, Alexei; Jastroch, Martin

Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets

成纤维细胞生长因子21通过促进缺乏蛋氨酸和胆碱饮食的小鼠肝脏脂肪酸活化来限制脂毒性。

Fisher, Ffolliott M; Chui, Patricia C; Nasser, Imad A; Popov, Yury; Cunniff, Jeremy C; Lundasen, Thomas; Kharitonenkov, Alexei; Schuppan, Detlef; Flier, Jeffrey S; Maratos-Flier, Eleftheria

Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21

肝脏SIRT1通过诱导成纤维细胞生长因子21来减轻小鼠肝脂肪变性并控制能量平衡

Li, Yu; Wong, Kimberly; Giles, Amber; Jiang, Jianwei; Lee, Jong Woo; Adams, Andrew C; Kharitonenkov, Alexei; Yang, Qin; Gao, Bin; Guarente, Leonard; Zang, Mengwei

Inventing new medicines: The FGF21 story

发明新药:FGF21的故事

Kharitonenkov, Alexei; Adams, Andrew C

Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones

噻唑烷二酮类药物的抗糖尿病作用并不需要成纤维细胞生长因子21。

Adams, Andrew C; Coskun, Tamer; Cheng, Christine C; O Farrell, Libbey S; Dubois, Susan L; Kharitonenkov, Alexei

Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue.

肝脏和脂肪组织中的 FGF21 对缺血性心肌的内分泌保护作用

Liu Shu Q, Roberts Derek, Kharitonenkov Alexei, Zhang Brian, Hanson Samuel M, Li Yan Chun, Zhang Li-Qun, Wu Yu H