A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice.
一种能穿过血脑屏障的肽-神经降压素缀合物,在小鼠癫痫持续状态后可诱导药理性低温,并具有抗惊厥、神经保护和抗炎特性
期刊:Elife
影响因子:6.4
doi:10.7554/eLife.100527
Ferhat Lotfi, Soussi Rabia, Masse Maxime, Kyriatzis Grigorios, Girard Stéphane, Gassiot Fanny, Gaudin Nicolas, Laurencin Mathieu, Bernard Anne, Bôle Angélique, Ferracci Géraldine, Smirnova Maria, Roman François, Dive Vincent, Cisternino Salvatore, Temsamani Jamal, David Marion, Lécorché Pascaline, Jacquot Guillaume, Khrestchatisky Michel