Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.
对抗叶酸化合物 QN254(5-氯-N'6'-(2,5-二甲氧基苄基)-喹唑啉-2,4,6-三胺)作为抗疟疾候选药物进行临床前评价
期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.01526-09
Nzila Alexis, Rottmann Matthias, Chitnumsub Penchit, Kiara Stevens M, Kamchonwongpaisan Sumalee, Maneeruttanarungroj Cherdsak, Taweechai Supannee, Yeung Bryan K S, Goh Anne, Lakshminarayana Suresh B, Zou Bin, Wong Josephine, Ma Ngai Ling, Weaver Margaret, Keller Thomas H, Dartois Veronique, Wittlin Sergio, Brun Reto, Yuthavong Yongyuth, Diagana Thierry T