日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation

通过变构配体和PROTAC诱导降解靶向剪接体蛋白USP39

Schäfer, Daniel; Prieto-Garcia, Cristian; Wang, Jianhui; Heinz, Marcel; Matkovic, Vigor; Kielkowski, Pavel; Hasselbeck, Sebastian; Shah, Varun Jayeshkumar; Knapp, Stefan; Hummer, Gerhard; Dikic, Ivan; Cheng, Xinlai

Horizontal transfer of post-translational modifiers brings evolutionary opportunity and challenges to a conserved translation factor

翻译后修饰基因的水平转移为保守的翻译因子带来了进化机遇和挑战。

Brewer, Tess E; Kielkowski, Pavel; Stritzel, Jingzhi; Meier-Rosar, Florian; Schlundt, Andreas; Lassak, Jürgen

A cysteine reactive chloroalkane probe enables HaloTag ligation for downstream chemical proteomics analysis

半胱氨酸反应性氯代烷烃探针可实现 HaloTag 连接,用于下游化学蛋白质组学分析。

Woo, Dong U; Lee, Yejin; Min, Cheol Woo; Kim, Sun Tae; Kang, Yang Jae; Abanti, Rubaba R; Wu, Dongqing; Kielkowski, Pavel

A cysteine reactive chloroalkane probe enables HaloTag ligation for downstream chemical proteomics analysis

一种半胱氨酸反应性氯代烷探针可实现 HaloTag 连接,用于下游化学蛋白质组学分析。

Abanti, Rubaba R; Wu, Dongqing; Kielkowski, Pavel

AdiY acts as a cytoplasmic pH sensor via histidine protonation to regulate acid stress adaptation in Escherichia coli

AdiY通过组氨酸质子化作为胞质pH传感器,调节大肠杆菌的酸胁迫适应。

Gallo, Giovanni; Brameyer, Sophie; Kuppermann, Sonja; Schneider, Sabine; Kielkowski, Pavel; Jung, Kirsten

Aberrant FICD-mediated AMPylation drives α-Synuclein pathology and overall protein dyshomeostasis in dopaminergic neurons in Parkinson's disease

帕金森病中,FICD介导的异常AMP化驱动多巴胺能神经元中α-突触核蛋白病理和整体蛋白质稳态失衡。

Koller, Aron; Hoffmann, Laura; Bluhm, Alexandra; Schweigert, Alina; Schneider, Yanni; Andert, Marie; Becker, Tobias; Zunke, Friederike; Beach, Thomas G; Serrano, Geidy E; Roßner, Steffen; Winkler, Jürgen; Kielkowski, Pavel; Xiang, Wei

Vimentin network dysregulation mediates neurite deficits in SNCA duplication Parkinson's patient-derived midbrain neurons.

波形蛋白网络失调介导 SNCA 重复帕金森病患者来源的中脑神经元的神经突缺陷

Schneider Yanni, Koller Aron, Schweigert Alina, Andert Marie, Hoffmann Laura, O'Brien Sydney, Seebauer Lukas, Plötz Sonja, Kielkowski Pavel, Winkler Jürgen, Schlachetzki Johannes C M, Xiang Wei

A Highly Reactive Cysteine-Targeted Acrylophenone Chemical Probe That Enables Peptide/Protein Bioconjugation and Chemoproteomics Analysis

一种高反应性的半胱氨酸靶向丙烯酰苯酮化学探针,可用于肽/蛋白质生物偶联和化学蛋白质组学分析。

Nuber, Constantin M; Milton, Anna V; Nissl, Benedikt; Isaza Alvarez, Maria C; Bissinger, Benjamin R G; Sathian, Manjima B; Pignot, Cedric D; Haberhauer, Annsophie; Wu, Dongqing; Douat, Céline; Schneider, Sabine; Hacker, Stephan M; Kielkowski, Pavel; Konrad, David B

Self-assembled PROTACs enable glycoproteins degradation in the living cells

自组装的PROTACs能够促进活细胞内糖蛋白的降解

Chen, Haoyu; Zang, Liu; Kielkowski, Pavel

AMPylation Regulates 5'-3' Exonuclease PLD3 Processing

AMP化调控5'-3'外切核酸酶PLD3的加工

Hoffmann, Laura; Eckl, Eva-Maria; Bérouti, Marleen; Pries, Michael; Koller, Aron; Guhl, Charlotte; Hellmich, Ute A; Hornung, Veit; Xiang, Wei; Jae, Lucas T; Kielkowski, Pavel