日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques

Smac 模拟物与 eCD4-Ig 联合使用可逆转恒河猴的潜伏感染,且不减少 SHIV 病毒库。

Pache, Lars; Bui, John K; Klouser, Lindsay M; Fennessey, Christine M; Noyola, Alexander C; Einhaus, Teresa; Zhu, Haiying; Stensland, Laurence; Leguizamo, Isai; Koroma, Abubakarr A; Teriete, Peter; Chang, W L William; Hyrien, Ollivier; Duggan, Natasha N; Heimann, Dominik; Pérez-Osorio, Ailyn C; Bar, Katharine J; Cosford, Nicholas Dp; Keele, Brandon F; Hartigan-O'Connor, Dennis J; Farzan, Michael; Gardner, Matthew R; Jerome, Keith R; Chanda, Sumit K; Kiem, Hans-Peter; Peterson, Christopher W

Transgenic mouse-derived human monoclonal antibodies targeting EBV gp350 and gp42 provide basis for therapeutic development.

针对 EBV gp350 和 gp42 的转基因小鼠来源的人类单克隆抗体为治疗开发提供了基础。

Chhan Crystal B, Lang Kevin, Davis Amelia R, Wan Yu-Hsin, Aldridge Nicholas T, Kher Gargi, Scharffenberger Samuel C, Hardy Samantha R, Iureniev Roman, Giltiay Natalia V, Edwards Kristina R, Radtke Stefan, Kiem Hans-Peter, Pancera Marie, McGuire Andrew T

Engraftment of gene-edited hematopoietic stem cells after antibody-drug conjugate conditioning in nonhuman primates

在非人灵长类动物中,经抗体药物偶联物预处理后基因编辑造血干细胞的移植

Murray, Jason; Einhaus, Teresa; Radtke, Stefan; Bar, Katharine J; Peterson, Christopher W; Kiem, Hans-Peter

In vitro evaluation of anti-HIV radioimmunoconjugates labeled with astatine-211, thorium-227 and actinium-225.

体外评价用砹-211、钍-227和锕-225标记的抗HIV放射免疫缀合物。

Kuhlmann Anne-Sophie, Hamlin Donald K, Li Yawen, Wang Xinyi, Li Lily, Orvig Chris, Kiem Hans-Peter, Sandmaier Brenda M, Wilbur D Scott, Pincus Seth, Harrington Robert D

Comparative In Vitro Evaluation of Anti-HIV Immunotoxin, Antibody-Drug Conjugate, and Radioimmunoconjugate Targeted by the Same Antibody

对靶向同一抗体的抗HIV免疫毒素、抗体-药物偶联物和放射免疫偶联物进行体外比较评价

Kuhlmann, Anne-Sophie; Peters, Tami; Hamlin, Donald K; Li, Yawen; Wang, Xinyi; Stackhouse, Megan; Cole, Frances M; Martinez-Reyes, Jasmin; Sandmaier, Brenda M; Kiem, Hans-Peter; Wilbur, D Scott; Harrington, Robert D; Pincus, Seth H

Pooled CAR-T screening in pig-tailed macaques identifies designs with enhanced proliferation, trafficking, and persistence

在豚尾猕猴中进行的混合 CAR-T 筛选鉴定出具有增强的增殖、迁移和持久性的设计。

Maynard, Lucy H; Cavanaugh, Eric J; Zhu, Haiying; Starke, Carly E; Doherty, Sarah M; Einhaus, Teresa; Pérez-Osorio, Ailyn C; Stensland, Laurence; Blair, Cameron; Roche, Aoife M; Everett, John K; Murnane, Robert D; Hoffman, Michelle; Nelson, Veronica; Herrin, Sarah; Littlewood, Chad; Camou, Kaycee; Wilson, Erica; Wessel, Christopher; Bushman, Frederic D; Jerome, Keith R; Kiem, Hans-Peter; Peterson, Christopher W

Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells

微环境来源的信号素4A保障髓系偏向造血干细胞的功能特性

Toghani, Dorsa; Gupte, Sanika; Zeng, Sharon; Mahammadov, Elmir; Crosse, Edie I; Seyedhassantehrani, Negar; Burns, Christian; Gravano, David; Radtke, Stefan; Kiem, Hans-Peter; Rodriguez, Sonia; Carlesso, Nadia; Pradeep, Amogh; Georgiades, Alexis; Lucas, Fabienne; Wilson, Nicola K; Kinston, Sarah J; Göttgens, Berthold; Zong, Le; Beerman, Isabel; Park, Bongsoo; Janssens, Derek H; Jones, Daniel; Toghani, Ali; Nerlov, Claus; Pietras, Eric M; Mesnieres, Marion; Maes, Christa; Kumanogoh, Atsushi; Worzfeld, Thomas; Cheong, Jin-Gyu; Josefowicz, Steven Z; Kharchenko, Peter; Scadden, David T; Scialdone, Antonio; Spencer, Joel A; Silberstein, Lev

Engraftment and persistence of HBB base-edited hematopoietic stem cells in nonhuman primates

HBB碱基编辑的造血干细胞在非人灵长类动物中的植入和持久性

Radtke, Stefan; Fields, Emily; Swing, Kyle; Kanestrom, Greta; Yen, Jonathan S; Pande, Dnyanada; Enstrom, Mark R; Humbert, Olivier; Weiss, Mitchell J; Liu, David R; Newby, Gregory A; Kiem, Hans-Peter

Protection of CD33-modified hematopoietic stem cell progeny from CD33-directed CAR T cells in rhesus macaques

在恒河猴中保护CD33修饰的造血干细胞后代免受CD33靶向CAR T细胞的攻击

Petty, Nicholas E; Radtke, Stefan; Kanestrom, Greta; Fields, Emily; Humbert, Olivier; Fiorenza, Salvatore; Llewellyn, Mallory J; Laszlo, George S; Thomas, Justin; Burger, Zach; Swing, Kyle; Zhu, Haiying; Jerome, Keith R; Turtle, Cameron J; Walter, Roland B; Kiem, Hans-Peter

A rescue fanconi anemia humanized mouse model with endogenous FA mutation and high human hematopoietic stem cell chimerism

一种具有内源性范可尼贫血突变和高人类造血干细胞嵌合率的人源化小鼠模型,可用于拯救范可尼贫血。

Choo, Seunga; Tong, Alvin H; Fields, Emily; Mack, Heather M; Humbert, Olivier; Radtke, Stefan; Kiem, Hans-Peter