The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
白血病相关 IDH1 和 IDH2 突变的共同特征是将 α-酮戊二酸转化为 2-羟基戊二酸的新酶活性
期刊:Cancer Cell
影响因子:48.8
doi:10.1016/j.ccr.2010.01.020
Patrick S Ward, Jay Patel, David R Wise, Omar Abdel-Wahab, Bryson D Bennett, Hilary A Coller, Justin R Cross, Valeria R Fantin, Cyrus V Hedvat, Alexander E Perl, Joshua D Rabinowitz, Martin Carroll, Shinsan M Su, Kim A Sharp, Ross L Levine, Craig B Thompson
