Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both in vitro and in vivo
体外和体内研究了调控PDE11A4与年龄相关的液-液相分离(LLPS)的分子机制,以及选择性强、高效且口服有效的PDE11A4小分子抑制剂对其的逆转作用。
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doi:10.1101/2025.05.20.654583
Amurrio, E; Patel, J; Danaher, M; Elzaree, L; Fisher, J L; Greene, H; Kargbo, P; Kim, P; Klimentova, E; Lin, S; Liu, Y; Mehboob, M Y; Abdallah, S; Temesgen, Y; Ul Mahmood, S; Rotella, D P; Kelly, M P