日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Lysine Demethylase KDM4C Is an Oncogenic Driver and Regulates ERK Activity in KRAS-Mutant Pancreatic Ductal Adenocarcinoma

赖氨酸去甲基化酶KDM4C是致癌驱动因子,并在KRAS突变型胰腺导管腺癌中调节ERK活性。

Menna-T-Allah Shaheen,Sarah Dhebat,Kimal I Rajapakshe,Bidyut Ghosh,Benson Chellakkan Selvanesan,Shariq S Ansari,Cara L Haymaker,Dorsay Sadeghian,Huamin Wang,Ching-Fei Li,Haoqiang Ying,Anirban Maitra

Deep Learning Enabled 3D Multi-Omic Analysis Reveals Molecular Signatures of Heterogeneous Response to Chemotherapy in Pancreatic Cancer

深度学习赋能的三维多组学分析揭示胰腺癌化疗异质性反应的分子特征

Forjaz, André; Mojdeganlou, Hengameh; Valentin, Alens; Wetzel, Meredith; Lvovs, Dmitrijs; Deshpande, Atul; Shin, Sarah M; Piya, Sujan; Rajapakshe, Kimal I; Guerrero, Paola A; Pedro, Brian A; Sidiropoulos, Dimitrios N; Wu, Pei-Hsun; Pagan, Vincent Bernard; Wirtz, Denis; Fertig, Elana J; Kagohara, Luciane T; Ho, Won Jin; Kiemen, Ashley L; Wood, Laura D; Christenson, Eric S; Freed-Pastor, William A; Iacobuzio-Donahue, Christine A; Karchin, Rachel; Karnoub, Elias-Ramzey; Maitra, Anirban; Melchor, Jerry; Park, Wungki; Matos-Romero, Valentina; O'Reilly, Eileen; Soares, Kevin C

Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics

单细胞空间多组学揭示癌症相关成纤维细胞的保守空间亚型和细胞邻域

Yunhe Liu ,Ansam Sinjab ,Jimin Min ,Guangchun Han ,Francesca Paradiso ,Yuanyuan Zhang ,Ruiping Wang ,Guangsheng Pei ,Yibo Dai ,Yang Liu ,Kyung Serk Cho ,Enyu Dai ,Akshay Basi ,Jared K Burks ,Kimal I Rajapakshe ,Yanshuo Chu ,Jiahui Jiang ,Daiwei Zhang ,Xinmiao Yan ,Paola A Guerrero ,Alejandra Serrano ,Mingyao Li ,Tae Hyun Hwang ,Andrew Futreal ,Jaffer A Ajani ,Luisa M Solis Soto ,Amir A Jazaeri ,Humam Kadara ,Anirban Maitra ,Linghua Wang

Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAF(V600E) metastatic colorectal cancer

恩科拉非尼、西妥昔单抗和纳武利尤单抗治疗微卫星稳定型BRAF(V600E)转移性结直肠癌的I/II期临床试验

Morris, Van K; Parseghian, Christine M; Bahrambeigi, Vahid; Abdelfattah, Nourhan; Xiao, Lianchun; Agrawal, Anjali; Lin, Kangyu; Raghav, Kanwal P S; Wolff, Robert A; Dasari, Arvind; Huey, Ryan W; Kee, Bryan K; Overman, Michael J; Willis, Jason A; Le, Phat H; Escano, Michelle; Baig, Yunyu C; Pan, Kelsey; Menter, David; Tam, Alda L; Foo, Wai C; Shen, Li; Lee, Hey Min; Gallup, Thomas D; Margain, Cori; Gallup, Dave; Rajapakshe, Kimal I; Guerrero, Paola A; Wang, Jing; Corcoran, Ryan B; Maitra, Anirban; Yun, Kyuson; Kopetz, Scott

An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer

一种不依赖于特定等位基因的突变型KRAS抑制剂可抑制肿瘤维持信号并重编程胰腺癌的肿瘤免疫。

McAndrews, Kathleen M; Paradiso, Francesca; Stalnecker, Clint A; Chellakkan, Benson S; Thege, Fredrik I; Peng, David H; Moreno Diaz, Barbara A; Sugimoto, Hikaru; Patel, Sarah I; Mahadevan, Krishnan K; Kirtley, Michelle L; Wills, Danielle; Sockwell, Amari M; Fonseca, Andre Luis F; Liu, Yunhe; Rajapakshe, Kimal I; Yee, Nathaniel G; Tran, Phuong Thao; Omar, Huda Alchikh; Tedeschi, Antonio; Schischlik-Siegl, Fiorella; Boghossian, Andrew S; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Rudolph, Dorothea; Aichinger, Martin; Ebner, Florian; Artemov, Artem V; Lipp, Jesse; Pisarsky, Laura; Herrmann, Valerie Laura; Park, John; Rippmann, Jörg F; Schaaf, Otmar; Chandler, Vanessa; Williams, Mariah; Deckard, Charles E; Wang, Linghua; Der, Channing J; Vellano, Christopher; Guerrero, Paola A; Heffernan, Timothy P; Kalluri, Raghu; Maitra, Anirban

A spatial atlas of chemoradiation therapy in pancreatic cancer identifies cellular and microenvironmental determinants of persister populations

胰腺癌放化疗的空间图谱揭示了持续性细胞群的细胞和微环境决定因素

Bernard, Vincent; Ku, Li-Ting; Wang, Tianyu; Acevedo-Diaz, Ariana; Rajapakshe, Kimal I; Jacobson, Galia; Tovar, Daniela; Min, Jimin; Pei, Guangsheng; Tat, Candise; Suresh, Ayush; Tzeng, Ching-Wei D; Katz, Matthew Hg; Bhutani, Manoop S; Wang, Huaming; Wolff, Robert A; Haymaker, Cara; Ludmir, Ethan B; Huang, Huocong; Chen, Xiongfeng; Li, Liang; Koong, Albert C; Wang, Linghua; Navin, Nicholas E; Jiang, Dadi; Li, Ziyi; Maitra, Anirban; Koay, Eugene J

Integrative analysis of genomic and transcriptomic data informs precancer progression in the pancreas

基因组和转录组数据的整合分析有助于了解胰腺癌前病变的进展

Noller, Kathleen; Lai, Jiaying; Lesperance, Daniel; Adkins, Ricky S; Elhossiny, Ahmed; Guerrero, Paola A; Rajapakshe, Kimal I; Maitra, Anirban; Giglio, Michelle; Mahurkar, Anup; White, Owen; Di Magliano, Marina Pasca; Ochs, Michael F; Kagohara, Luciane T; Wood, Laura D; Karchin, Rachel; Fertig, Elana J

Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas

突变型GNAS引起的代谢重编程在胰腺导管内乳头状黏液性肿瘤中产生了可操作的依赖性

Makino, Yuki; Rajapakshe, Kimal I; Chellakkan Selvanesan, Benson; Okumura, Takashi; Date, Kenjiro; Dutta, Prasanta; Abou-Elkacem, Lotfi; Sagara, Akiko; Min, Jimin; Sans, Marta; Yee, Nathaniel; Siemann, Megan J; Enriquez, Jose; Smith, Paytience; Bhattacharya, Pratip; Kim, Michael; Dede, Merve; Hart, Traver; Maitra, Anirban; Thege, Fredrik Ivar

Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype

血浆细胞外囊泡的转录组分析能够可靠地注释癌症特异性转录组和分子亚型

Bahrambeigi, Vahid; Lee, Jaewon J; Branchi, Vittorio; Rajapakshe, Kimal I; Xu, Zhichao; Kui, Naishu; Henry, Jason T; Kun, Wang; Stephens, Bret M; Dhebat, Sarah; Hurd, Mark W; Sun, Ryan; Yang, Peng; Ruppin, Eytan; Wang, Wenyi; Kopetz, Scott; Maitra, Anirban; Guerrero, Paola A

Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses

全基因组 p63 靶基因分析揭示 TAp63/NRF2 依赖的氧化应激反应

Marco Napoli, Avani A Deshpande, Deepavali Chakravarti, Kimal Rajapakshe, Preethi H Gunaratne, Cristian Coarfa, Elsa R Flores