日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

发现 AG-120 (Ivosidenib):用于治疗 IDH1 突变型癌症的同类首创突变型 IDH1 抑制剂

Janeta Popovici-Muller, René M Lemieux, Erin Artin, Jeffrey O Saunders, Francesco G Salituro, Jeremy Travins, Giovanni Cianchetta, Zhenwei Cai, Ding Zhou, Dawei Cui, Ping Chen, Kimberly Straley, Erica Tobin, Fang Wang, Muriel D David, Virginie Penard-Lacronique, Cyril Quivoron, Véronique Saada, Stép

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2

突变型IDH1下调ATM表达,并改变DNA修复和对DNA损伤的敏感性,且该过程独立于TET2。

Satoshi Inoue ,Wanda Y Li ,Alan Tseng ,Isabel Beerman ,Andrew J Elia ,Sean C Bendall ,François Lemonnier ,Ken J Kron ,David W Cescon ,Zhenyue Hao ,Evan F Lind ,Naoya Takayama ,Aline C Planello ,Shu Yi Shen ,Alan H Shih ,Dana M Larsen ,Qinxi Li ,Bryan E Snow ,Andrew Wakeham ,Jillian Haight ,Chiara Gorrini ,Christian Bassi ,Kelsie L Thu ,Kiichi Murakami ,Alisha R Elford ,Takeshi Ueda ,Kimberly Straley ,Katharine E Yen ,Gerry Melino ,Luisa Cimmino ,Iannis Aifantis ,Ross L Levine ,Daniel D De Carvalho ,Mathieu Lupien ,Derrick J Rossi ,Garry P Nolan ,Rob A Cairns ,Tak W Mak

Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma

将 2-羟基戊二酸质子磁共振波谱技术整合到临床实践中用于异柠檬酸脱氢酶突变型胶质瘤的疾病监测

Macarena I de la Fuente, Robert J Young, Jennifer Rubel, Marc Rosenblum, Jamie Tisnado, Samuel Briggs, Julio Arevalo-Perez, Justin R Cross, Carl Campos, Kimberly Straley, Dongwei Zhu, Chuanhui Dong, Alissa Thomas, Antonio A Omuro, Craig P Nolan, Elena Pentsova, Thomas J Kaley, Jung H Oh, Ralph Noesk

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

IDH2 突变诱导的组蛋白和 DNA 高甲基化可通过小分子抑制逐渐逆转

Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley, Camelia Gliser, Hua Yang, Jeremy Travins, Stuart Murray, Marion Dorsch, Sam Agresta, David P Schenkein, Scott A Biller, Shinsan M Su, Wei Liu, Katharine E Yen

Mutant IDH is sufficient to initiate enchondromatosis in mice

突变IDH足以引发小鼠的软骨瘤病

Makoto Hirata, Masato Sasaki, Rob A Cairns, Satoshi Inoue, Vijitha Puviindran, Wanda Y Li, Bryan E Snow, Lisa D Jones, Qingxia Wei, Shingo Sato, Yuning J Tang, Puviindran Nadesan, Jason Rockel, Heather Whetstone, Raymond Poon, Angela Weng, Stefan Gross, Kimberly Straley, Camelia Gliser, Yingxia Xu, 

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance

突变IDH2在白血病发生和维持中的原癌作用

Lev M Kats, Markus Reschke, Riccardo Taulli, Olga Pozdnyakova, Kerri Burgess, Parul Bhargava, Kimberly Straley, Rahul Karnik, Alexander Meissner, Donald Small, Shinsan M Su, Katharine Yen, Jiangwen Zhang, Pier Paolo Pandolfi