日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A B7-H4-Targeting Antibody-Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

靶向 B7-H4 的抗体-药物偶联物在 PARPi 和具有 B7-H4 表达的铂耐药癌症中表现出抗肿瘤活性

Sarah B Gitto #, Margaret Whicker #, Gareth Davies #, Sushil Kumar, Krista Kinneer, Haineng Xu, Arthur Lewis, Srinivas Mamidi, Sergey Medvedev, Hyoung Kim, Judith Anderton, E Jessica Tang, Benjamin Ferman, Steven Coats, Robert W Wilkinson, Eric Brown, Daniel J Powell Jr, Fiona Simpkins

Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying Its Stability In Vivo

对抗B7-H4抗体-药物偶联物AZD8205进行广泛的生物转化分析,阐明了其体内稳定性的潜在途径

Huang, Yue; Tan, Hui Yin; Yuan, Jiaqi; Mu, Ruipeng; Yang, Junyan; Ball, Kathryn; Vijayakrishnan, Balakumar; Masterson, Luke; Kinneer, Krista; Luheshi, Nadia; Liang, Meina; Rosenbaum, Anton I

Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors

腺样囊性癌的空间免疫分析揭示B7-H4是侵袭性肿瘤的治疗靶点

Sousa, Luana Guimaraes; McGrail, Daniel J; Lazar Neto, Felippe; Li, Kaiyi; Marques-Piubelli, Mario L; Ferri-Borgogno, Sammy; Dai, Hui; Mitani, Yoshitsugu; Spardy Burr, Nicole; Cooper, Zachary A; Kinneer, Krista; Cortez, Maria Angelica; Lin, Shiaw-Yih; Bell, Diana; El Naggar, Adel; Burks, Jared; Ferrarotto, Renata

BCMA-Specific ADC MEDI2228 and Daratumumab Induce Synergistic Myeloma Cytotoxicity via IFN-Driven Immune Responses and Enhanced CD38 Expression

BCMA 特异性 ADC MEDI2228 和达雷木单抗通过 IFN 驱动的免疫反应和增强的 CD38 表达诱导协同骨髓瘤细胞毒性

Lijie Xing, Su Wang, Jiye Liu, Tengteng Yu, Hailin Chen, Kenneth Wen, Yuyin Li, Liang Lin, Phillip A Hsieh, Shih-Feng Cho, Gang An, Lugui Qiu, Krista Kinneer, Nikhil Munshi, Kenneth C Anderson, Yu-Tzu Tai

Characterization and in vitro data of antibody drug conjugates (ADCs) derived from heterotrifunctional linker designed for the site-specific preparation of dual ADCs

对源自异三功能连接子的抗体药物偶联物(ADC)进行表征和体外数据分析,该连接子旨在用于位点特异性制备双重ADC。

Kumar, Amit; Kinneer, Krista; Masterson, Luke; Ezeadi, Ebele; Howard, Philip; Wu, Herren; Gao, Changshou; Dimasi, Nazzareno

A Potent HER3 Monoclonal Antibody That Blocks Both Ligand-Dependent and -Independent Activities: Differential Impacts of PTEN Status on Tumor Response

阻断配体依赖性和非配体依赖性活性的强效 HER3 单克隆抗体:PTEN 状态对肿瘤反应的不同影响

Zhan Xiao, Rosa A Carrasco, Kevin Schifferli, Krista Kinneer, Ravinder Tammali, Hong Chen, Ray Rothstein, Leslie Wetzel, Chunning Yang, Partha Chowdhury, Ping Tsui, Philipp Steiner, Bahija Jallal, Ronald Herbst, Robert E Hollingsworth, David A Tice

A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo

针对 EphA2 的人类抗体-药物偶联物可抑制体内肿瘤生长

Dowdy Jackson, John Gooya, Shenlan Mao, Krista Kinneer, Linda Xu, Margarita Camara, Christine Fazenbaker, Ryan Fleming, Sudha Swamynathan, Damon Meyer, Peter D Senter, Changshou Gao, Herren Wu, Michael Kinch, Steven Coats, Peter A Kiener, David A Tice